34603-35-5

Usage

Uses

Used in Pharmaceutical Research:
(3S,10R,13S,14R)-3-HYDROXY-10,13-DIMETHYL-3,4,7,8,9,10,11,12,13,14-DECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17(2H)-ONE is used as a potential pharmaceutical candidate for various applications due to its unique structure and functional groups. Its biological activity and steroidal nature make it a promising compound for further research and development in the field of medicine.
Used in Drug Development:
In the drug development industry, (3S,10R,13S,14R)-3-HYDROXY-10,13-DIMETHYL-3,4,7,8,9,10,11,12,13,14-DECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17(2H)-ONE is used as a starting material or a scaffold for the design and synthesis of new drugs. Its complex molecular structure and the presence of multiple functional groups provide opportunities for modification and optimization to enhance its therapeutic potential.
Used in Chemical Synthesis:
(3S,10R,13S,14R)-3-HYDROXY-10,13-DIMETHYL-3,4,7,8,9,10,11,12,13,14-DECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17(2H)-ONE is used as an intermediate in the synthesis of other complex organic compounds. Its unique structure and functional groups make it a valuable building block for the creation of novel molecules with potential applications in various fields, including materials science, agrochemicals, and specialty chemicals.

Upstream product

• 32206-51-2 (8R,9S,10R,13S,14S)-10,13-Dimethyl-3,17-bis-trimethylsilanyloxy-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthrene 
• 162460-24-4 17,17-ethylenedioxy-3β-hydroxyandrosta-5,14-diene 
• 151434-12-7 16-bromo-3β-hydroxy-5-androsten-17-one 
• 34635-41-1 3β-hydroxyandrosta-5,14-dien-17-one 
• 32206-51-2 10,13-Dimethyl-3,17-bis-trimethylsilanyloxy-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthrene 

Relevant academic research and scientific papers

A facile total synthesis of drospirenone isomers containing 14β-hydrogen configuration

A facile strategy for the preparation of two isomeric drospirenones 13 and 16 possessing a 14β-hydrogen was developed, using 3β-hydroxyandrost-5- en-17-one as the starting material. The total synthetic route involves eight steps, giving 2% overall yield. The structures of the main compounds 11, 13, 14 and 16 were determined by single crystal XRD analysis.

NEW SYNTHETIC METHODS FOR α,β-UNSATURATED KETONES, ALDEHYDES, ESTERS AND LACTONES BY THE PALLADIUM-CATALYZED REACTIONS OF SILYL ENOL ETHERS, KETENE SILYL ACETALS, AND ENOL ACETATES WITH ALLYL CARBONATES

Silyl enol ethers and ketene silyl acetals derived from ketones, aldehydes, esters and lactones are converted into α,β-unsaturated ketones, aldehydes and lactones by treatment with allyl carbonates in high yields using the palladium-bis(diphenylphosphino)ethane (dppe) complex as catalyst.Phosphine-free palladium catalyst instead of the palladium-phosphine complex gives a higher selectivity for the preparation of cyclopentenone, cyclooctenone, dienones, α,β-unsaturated esters and lactones.As a solvent, the use of nitriles such as acetonitrile is essential.In other solvents, allylation takes place.Enol acetates derived from ketones are converted into α,β-unsaturated ketones by reaction with allyl carbonate in acetonitrile using the palladium complex and tributyltin methoxide as bimetallic catalysts.

A NOVEL PALLADIUM-CATALYZED PREPARATIVE METHOD OF α,β-UNSATURATED KETONES AND ALDEHYDES FROM SATURATED KETONES AND ALDEHYDES VIA THEIR SILYL ENOL ETHERS

Silyl enol ethers prepared from saturated ketones and aldehydes can be converted to α,β-unsaturated ketones and aldehydes by the reaction of allyl carbonate in the presence of palladium-phosphine complexes as a catalyst.The selection of solvent is crucial and nitriles are most effective as the solvent.