34627-62-8 Usage
Uses
Used in Organic Synthesis:
3'-CHLORO-3'-DEOXY-5'-O-TRITYLTHYMIDINE is used as a synthetic intermediate for the development of various pharmaceuticals and bioactive molecules. Its unique structure allows for the creation of new compounds with potential applications in the medical and pharmaceutical industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3'-CHLORO-3'-DEOXY-5'-O-TRITYLTHYMIDINE is used as a key component in the synthesis of antiviral and anticancer drugs. Its ability to be modified and incorporated into larger molecules makes it a valuable tool in the development of new therapeutic agents.
Used in Research and Development:
3'-CHLORO-3'-DEOXY-5'-O-TRITYLTHYMIDINE is also utilized in research and development laboratories for the study of its chemical properties and potential applications. Scientists and researchers use 3'-CHLORO-3'-DEOXY-5'-O-TRITYLTHYMIDINE to explore new methods of synthesis and to investigate its interactions with other molecules, which can lead to the discovery of novel therapeutic approaches.
Used in Drug Design:
In the field of drug design, 3'-CHLORO-3'-DEOXY-5'-O-TRITYLTHYMIDINE is used as a starting material for the creation of new drug candidates. Its unique chemical properties make it an attractive option for the development of targeted therapies, which can potentially lead to more effective treatments with fewer side effects.
Overall, 3'-CHLORO-3'-DEOXY-5'-O-TRITYLTHYMIDINE is a versatile compound with a wide range of applications in various industries, particularly in the fields of organic synthesis, pharmaceuticals, and drug design. Its unique structure and properties make it a valuable tool for researchers and scientists working to develop new and innovative treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 34627-62-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,6,2 and 7 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 34627-62:
(7*3)+(6*4)+(5*6)+(4*2)+(3*7)+(2*6)+(1*2)=118
118 % 10 = 8
So 34627-62-8 is a valid CAS Registry Number.
34627-62-8Relevant academic research and scientific papers
3′-Bromo analogues of pyrimidine nucleosides as a new class of potent inhibitors of mycobacterium tuberculosis
Shakya, Neeraj,Srivastav, Naveen C.,Desroches, Nancy,Agrawal, Babita,Kunimoto, Dennis Y.,Kumar, Rakesh
experimental part, p. 4130 - 4140 (2010/09/04)
Tuberculosis (TB) is a major health problem worldwide. We herein report a new class of pyrimidine nucleosides as potent inhibitors of Mycobacterium tuberculosis (M. tuberculosis). Various 2′- or 3′-halogeno derivatives of pyrimidine nucleosides containing uracil, 5-fluorouracil, and thymine bases were synthesized and evaluated for antimycobacterial activities. Among the compounds tested, 3′-bromo-3′-deoxy- arabinofuranosylthymine (33) was the most effective antituberculosis agent in the in vitro assays against wild-type M. tuberculosis strain (H37Ra) (MIC 50 = 1 μg/mL) as well as drug-resistant (H37Rv) (rifampicin-resistant and isoniazid-resistant) strains of M. tuberculosis (MIC50 = 1-2 μg/mL). Compound 33 also inhibited intracellular M. tuberculosis in a human monocytic cell line infected with H37Ra, demonstrating higher activity against intramacrophagic mycobacteria (80% reduction at 10 μg/mL concentration) than extracellular mycobacteria (75% reduction at 10 μg/mL concentration). In contrast, pyrimidine nucleosides possessing 5-fluorouracil base were weak inhibitors of M. tuberculosis. No cytotoxicity was found up to the highest concentration of compounds tested (CC50 > 100-200 μg/mL) against a human cell line. Overall, these encouraging results substantiate the potential of this new class of compounds as promising antituberculosis agents.
