3463-33-0

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-chlorophenyl)-2-propyn-1-one is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new medications due to its unique chemical structure.
Used in Organic Chemical Production:
1-(2-chlorophenyl)-2-propyn-1-one serves as a reactant in the production of other organic compounds, highlighting its versatility in chemical reactions and its utility in creating a range of products.
Used as a Building Block in Synthesis:
1-(2-chlorophenyl)-2-propyn-1-one can be employed as a building block in the synthesis of more complex molecules, showcasing its importance in the construction of intricate chemical structures.
Used in Biological and Pharmacological Research:
Given its potential as an anti-inflammatory and antifungal agent, 1-(2-chlorophenyl)-2-propyn-1-one is used in research aimed at discovering and developing novel treatments for various conditions.
Used in Chemical Research and Development:
1-(2-chlorophenyl)-2-propyn-1-one is also utilized in the field of chemical research and development, where it may contribute to the advancement of chemical knowledge and the creation of innovative applications.
Safety Note:
It is crucial to handle 1-(2-chlorophenyl)-2-propyn-1-one with care, as it can be an irritant to the skin, eyes, and respiratory system, emphasizing the need for proper safety measures during its use.

Upstream product

• 19115-29-8 1-(2-chlorophenyl)-2-propyn-1-ol 
• 609-65-4 o-chlorobenzoyl chloride 
• 74-86-2 acetylene 

Downstream Products

• 1380094-65-4 C₁₁H₁₁ClOS 
• 1284175-84-3 C₁₁H₁₁ClOS 

Relevant academic research and scientific papers

A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.

Oxidation of propargylic alcohols with a 2-quinoxalinol salen copper(II) complex and tert-butyl hydroperoxide

The copper(II) complex of 2-quinoxalinol salen (salqu) is an efficient catalyst for the selective oxidation of propargylic alcohols to yield the corresponding α,β-acetylenic carbonyl compounds when used in combination with the oxidant tert-butyl hydroperoxide (TBHP). Excellent yields (up to 99 %) are achieved for a variety of propargylic alcohols within 1 h of reaction time. The (salqu)copper(II) complex with TBHP can be used with propargylic alcohols that contain alkyl groups in the α-position, which can be difficult to oxidize selectively with other commonly available methods. By using this catalytic protocol, excellent selectivity was also achieved for the oxidation of propargylic alcohols over that of isolated hydroxy groups, triple bonds, or propargylic methylene groups. The 2-quinoxalinol salen copper(II) complex is an efficient catalyst when used with tert-butyl hydroperoxide for the oxidation of propargylic alcohols to yield the corresponding carbonyl compounds. This catalytic system provides excellent selectivity for the reaction with propargylic alcohols, and high yields (up to 99 %) are achieved within 1 h and with 1 mol-% of catalyst loading. Copyright

Microwave-assisted three-component coupling-addition-SNAr (CASNAR) sequences to annelated 4H-thiopyran-4-ones

A whole family of annelated 4H-thiopyran-4-ones as the core structural unit was readily synthesized in good yields by a microwave-assisted coupling-addition-SNAr (CASNAR) sequence starting from readily available (het)aroyl chlorides, alkynes and sodium sulfide nonahydrate in a consecutive one-pot three-component reaction. All representatives display a pronounced halochromicity of the absorption bands upon protonation. According to DFT calculations, the electronic ground state of the annelated 4H-thiopyran-4-ones possess a considerable zwitterionic character. The Royal Society of Chemistry 2010.

Calcium phosphate-vanadate apatite (CPVAP)-catalyzed aerobic oxidation of propargylic alcohols with molecular oxygen

Calcium phosphate-vanadate apatite (CPVAP) works effectively as a catalyst for the aerobic oxidation of propargylic alcohols to the corresponding carbonyl compounds under an atmospheric pressure of molecular oxygen. Moreover, CPVAP can be readily separated by filtration and reused at least 10 times without appreciable loss of the catalytic activity.

Oxovanadium complex-catalyzed aerobic oxidation of propargylic alcohols

A catalytic system consisting of vanadium oxyacetylacetonate [VO(acac)2] and 3 A molecular sieves (MS3A) in acetonitrile works effectively for the aerobic oxidation of propargylic alcohols [R1CH-(OH)C≡CR2] to the corresponding carbonyl compounds under an atmospheric pressure of molecular oxygen. Although the reactivity of α-acetylenic alkanols (R1 = alkyl) is lower compared to that of the alcohols of R1 = aryl, alkenyl, and alkynyl, the use of VO(hfac)2 as a catalyst and the addition of hexafluoroacetylacetone improve the product yield in these cases. A catalytic cycle involving a vanadium(V) alcoholate species and β-hydrogen elimination from it has been proposed for this oxidation.