34633-09-5

Usage

Uses

Used in Pharmaceutical Research:
4-IODOCINNAMIC ACID is used as a building block for the synthesis of potential drug candidates due to its ability to participate in various chemical reactions and its unique structural features.
Used in Organic Synthesis:
4-IODOCINNAMIC ACID is used as a versatile intermediate in organic synthesis for the production of a variety of compounds, leveraging its reactivity and functional groups.
Used in Medicinal Chemistry:
4-IODOCINNAMIC ACID is used as a starting material in medicinal chemistry to explore its potential in the development of new pharmaceuticals, given its structural attributes and chemical reactivity.
Used in the Production of Fine Chemicals and Specialty Products:
4-IODOCINNAMIC ACID is utilized as a valuable intermediate in the creation of fine chemicals and specialty products, capitalizing on its capacity to undergo diverse chemical transformations.

InChI:InChI=1/C9H7IO2/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6H,(H,11,12)/b6-3+

Upstream product

• 621-82-9 Cinnamic acid 
• 2033-24-1 cycl-isopropylidene malonate 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 141-82-2 malonic acid 
• 2393-18-2 p-aminocinnamic acid 

Downstream Products

• 1643-29-4 3-(4-iodophenyl)propionic acid 
• 66432-13-1 N-[(E)-2-(4-Iodo-phenyl)-vinyl]-formamide 
• 7400-08-0 para-coumaric acid 
• 501-52-0 3-Phenylpropionic acid 
• 1335096-75-7 (2E)-3-{4-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]phenyl}prop-2-enoic acid 

Relevant academic research and scientific papers

Radical-Cation Vinylcyclopropane Rearrangements by TiO2Photocatalysis

Radical cation vinylcyclopropane rearrangements by TiO2 photocatalysis in lithium perchlorate/nitromethane solution are described. The reactions are triggered by oxidative single electron transfer, which is followed by immediate ring-opening of the cyclopropanes to generate distonic radical cations as unique reactive intermediates. This approach can also be applied to vinylcyclobutane, leading to the construction of six-membered rings. A stepwise mechanism via distonic radical cations is proposed based on preliminary mechanistic studies, which is supported by density functional theory calculations.

Compound capable of being strongly bound with alpha-synuclein aggregate, and preparation method and use of compound

The invention belongs to the technical field of medicine, and relates to a compound with a structural general formula I, and a preparation method and use of the compound. In the formula I, R1 is selected from phenyl, substituted phenyl, pyridyl and pyrimidinyl, and i is selected from 0 to 2, and is an integer; R2 is selected from alkyl, phenyl, substituted phenyl and 5-6-membered aromatic heterocyclic rings, and m is selected from 0 to 5, and is an integer; and R3 is selected from phenyl and substituted phenyl, and n is selected from 0 to 3, and is an integer. The compound comprises a cis-isomer, a trans-isomer or a mixture of the cis-isomer and the trans-isomer of the compound with the formula I structure. The compound can be strongly bound to an alpha-synuclein aggregate, can be used asan imaging tracer for the image technology such as PET, SPECT and the like, or can be used for preparing an imaging tracer and a composition containing the imaging tracer, the compound can be used forparticularly detecting Parkinson's disease or neurological disorders associated with the misfolding and aggregation of alpha-synuclein, and the compound has very good application prospects.

A green chemical synthesis of coumarin-3-carboxylic and cinnamic acids using crop-derived products and waste waters as solvents

Crop-derived products, like juices obtained from edible fruits and vegetables, and waste waters deriving from agricultural and industrial processing have been recently exploited to efficiently promote several ‘classic’ and innovative synthetic organic reactions. Such a green chemical approach prevented the use of toxic, polluting, and hazardous materials and in the mean time allowed to increase the commercial values of crop products and industrial byproducts. Coumarin-3-carboxylic and cinnamic acids represent classes of naturally occurring and semi-synthetic compounds with interesting and promising pharmacological activities. In this Letter a new and improved methodology for the Knoevenagel condensation yielding the title compounds using juices from edible fruits and vegetables (lemon, grapefruit, carrot, pomegranate, kiwi, vinegar, tomato), liqueurs (limoncello), and waste waters (buttermilk and residues of olive processing) as solvents is described. Coumarin-3-carboxylic and cinnamic acids have been synthesized in excellent yields by ultrasound irradiation from differently substituted 2-hydroxybenzaldehydes, 2-hydroxyacetophenones, and benzaldehydes, and Meldrum's acid as starting substrates. The findings described herein enforce the concept of the usefulness of products and byproducts derived from agriculture and food industry to accomplish green chemical processes.

An electroluminescent compound and an electroluminescent device comprising the same

The present invention relates to an organic light emitting compound adopted to an organic electroluminescent device. The organic light emitting compound is represented by chemical formula 1. In the case of adopting the same as a dopant compound in a lumin