34635-34-2

Basic information

• Product Name: Phenylalanine, N-[(4-methylphenyl)sulfonyl]-
• CAS NO: 34635-34-2
• Molecular Formula: C16H17NO4S
• Molecular Weight: 319.381
• Mol File: 34635-34-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Phenylalanine, N-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenylalanine, N-[(4-methylphenyl)sulfonyl]-(34635-34-2)
• EPA Substance Registry System: Phenylalanine, N-[(4-methylphenyl)sulfonyl]-(34635-34-2)

Safety Data

• Hazardous Substances Data: 34635-34-2(Hazardous Substances Data)

Usage

General Description

Phenylalanine, N-[(4-methylphenyl)sulfonyl]- is a chemical compound that is a derivative of the amino acid phenylalanine. It is commonly known as a selective inhibitor of cyclooxygenase-2 (COX-2), an enzyme responsible for inflammation and pain. Phenylalanine, N-[(4-methylphenyl)sulfonyl]- has been studied for its potential therapeutic applications in treating various inflammatory conditions, such as arthritis and cancer. It works by binding to the active site of COX-2, preventing the production of inflammatory prostaglandins. Additionally, it has been investigated for its potential role in reducing cancer cell proliferation and promoting apoptosis. However, further research is needed to fully understand its mechanisms and potential applications in clinical settings.

Upstream product

• 150-30-1 Phenylalanine 
• 98-59-9 p-toluenesulfonyl chloride 
• 158109-81-0 cis-(2S,3S)-(+)-N-(p-toluenesulfonyl)-2-carbomethoxy-3-phenylaziridine 
• 163013-11-4 methyl trans-2-(N-(p-tolylsulfonyl)amino)cinnamate 

Downstream Products

• 78220-94-7 2-(N-Tos-DL-Phe)-aminobenzothiazole 
• 129673-46-7 3-Phenyl-2-(toluene-4-sulfonylamino)-propionic acid (3R,4R)-4-hydroxy-4-methyl-tetrahydro-pyran-3-yl ester 
• 21668-99-5 1-methyl-4-((4-methylbenzyl)sulfonyl)benzene 

Relevant articles and documents

Sulfonamide phenylalanine (SPA) series of analogues as an antibacterial, antifungal, anticancer agents along with p53 tumor suppressor-DNA complex inhibitor–part 1

A series of N-[1-benzyl-2-oxo-2-substituted(ethyl)] benzene/p-toluene sulfonamide (K1–K12) are synthesized. Structure of the synthesized analogues has been confirmed by FT-IR, 1H & 13C NMR and ESI-MS spectroscopic techniques. All the

Silver-Catalyzed C(sp3)-H Sulfonylation for the Synthesis of Benzyl Sulfones Using Toluene Derivatives and α-Amino Acid Sulfonamides

We describe a simple and practical protocol for the synthesis of benzyl sulfones using readily available toluene derivatives and α-amino acid sulfonamides. The reaction proceeds to afford a broad range of benzyl sulfones in moderate to high yields under silver catalysis. The mechanism possibly involves a Minisci-type formation of α-aminoalkyl radical, homolytic cleavage of a N-S bond to generate a sulfonyl radical, and coupling of sulfonyl radical with a benzyl radical formed via hydrogen abstraction by sulfate anion radical. The practicality of the present reaction is demonstrated by a gram-scale synthesis and one-step synthesis of anticancer-active compound. The mechanism studies are conducted using radical scavengers and deuterated toluene.

Pd(ii)-Catalyzed aerobic 1,2-difunctionalization of conjugated dienes: Efficient synthesis of morpholines and 2-morpholones

A novel and efficient methodology concerning the Pd(ii)-catalyzed intermolecular difunctionalization of conjugated dienes is reported to synthesize a series of functionalized morpholines and 2-morpholones. Widely distributed and easily obtained β-amino alcohols and α-amino acids, as starting nitrogen and oxygen sources, are successfully applied in the difunctionalization of conjugated dienes respectively. The majority of the desired products were obtained in moderate to excellent yields. Oxygen was successfully employed as a terminal oxidant. Further transformation of the generated products allowed for the expansion of structural diversity.