34636-92-5

Usage

Uses

Used in Organic Chemistry Research:
2-Methoxy-5-(trifluoromethyl)benzonitrile is used as a key intermediate in the synthesis of various chemical products for its unique structural features and reactivity.
Used in Pharmaceutical Industry:
2-Methoxy-5-(trifluoromethyl)benzonitrile is used as a building block in the development of new pharmaceuticals, leveraging its electron-withdrawing and electron-donating properties to enhance the activity and selectivity of drug candidates.
Used in Agrochemical Industry:
2-Methoxy-5-(trifluoromethyl)benzonitrile is used as a precursor in the synthesis of agrochemicals, contributing to the creation of novel compounds with improved pesticidal properties.

InChI:InChI=1/C9H6F3NO/c1-14-8-3-2-7(9(10,11)12)4-6(8)5-13/h2-4H,1H3

Upstream product

• 261951-78-4 1-fluoro-2-methoxy-4-(trifluoromethyl)benzene 
• 1261835-37-3 1,2-dimethoxy-4-(trifluoromethyl)benzene 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 72082-62-3 4-{[1-(2-Hydroxy-5-trifluoromethyl-phenyl)-1-(3-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-butyramide 
• 72082-61-2 4-{[1-(2-Hydroxy-5-trifluoromethyl-phenyl)-1-(4-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-butyramide 
• 72082-64-5 4-{[1-(4-Fluoro-phenyl)-1-(2-hydroxy-5-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-butyramide 
• 72082-63-4 4-{[1-(4-Fluoro-phenyl)-1-(2-hydroxy-5-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-butyric acid 
• 400771-42-8 (2-methoxy-5-(trifluoromethyl)phenyl)methanamine 
• 72082-67-8 4-{[1-(2-Hydroxy-5-trifluoromethyl-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-butyric acid 
• 72089-85-1 4-{[1-(2-Hydroxy-5-trifluoromethyl-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-butyramide 
• 72083-15-9 (2-methoxy-5-trifluoromethyl-phenyl)-phenyl-methanone 

Relevant academic research and scientific papers

Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution

Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluotomethylbenzylamine represented by the following general formula (1), 1where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4. The process includes hydrogenating a trifluoromethylbenzonitrile by hydrogen in an organic solvent in the presence of ammonia and a catalyst containing a platinum group element. This trifluoromethylbenzonitrile is represented by the following general formula (2), 2where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine at an extremely high yield.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluoromethylbenzylamine represented by the following general formula (1). This process includes hydrogenating a trifliuoromethylbenzonitrile represented by the following general formula (2) by hydrogen in an organic solvent in the presence of ammonia, using a Raney catalyst, where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4, where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine easily and inexpensively at an extremely high yield.