346433-42-9

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 89-95-2 2-methyl-benzyl alcohol 
• 90-02-8 salicylaldehyde 

Downstream Products

• 18272-63-4 2-(but-3-en-2-yl)phenol 
• 4237-44-9 2-(1-phenylethyl)phenol 
• 88-69-7 2-(1-methylethyl)phenol 
• 942588-45-6 carbonic acid tert-butyl ester 2-hydroxymethyl-phenyl ester 
• 1448543-85-8 2-(2-benzoyl-3-oxo-3-phenylprop-1-enyl)phenyl 4-bromobenzoate 
• 1448543-88-1 C₃₆H₂₂Br₂O₄ 
• 1448543-84-7 2-(2-hydroxybenzylidene)-1,3-diphenylpropane-1,3-dione 

Relevant academic research and scientific papers

Studies on the synthesis of furanosteroids. I. Viridin models

Alkyne oxazoles of general structure I are transformed directly to furo[2,3-b]phenol derivatives II by a sequence involving intramolecular Diels-Alder/retro-Diels-Alder reaction followed by tautomerization. Suitably functionalized phenols II undergo an intramolecular phenol-dienone-aldol condensation, generating the A,B,E-ring skeleton III characteristic of the viridin (1) class of furanosteroids.

NOVEL PEROXIDE DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR USE IN HUMAN MEDICINE AND IN COSMETICS FOR THE TREATMENT OR PREVENTION OF ACNE

The present invention relates to the use of the compounds of following general formula (I): It also relates to their process of preparation and to their therapeutic application.

Method for synthesizing furanosteroids

The present invention is a method for synthesizing furanosteroids. The method involves intramolecular Diels-Alder/retro-Diels-Alder reaction and tautomerization of a functionalized alkyne oxazole to produce a furo[2,3-b]phenol derivative which is elaborated by intermolecular and intramolecular condensations to generate ring-A of the furanosteroid. Furanosteroids and pharmaceutical compositions containing the same are also provided.

Organocatalytic methods for chemoselective O-tert-butoxycarbonylation of phenols and their regeneration from the O-t-Boc derivatives

(Chemical Equation Presented) Carbon tetrabromide (CBr4) catalyzes O-tert-butoxycarbonylation of functionalized phenols without any side reactions (bromination, addition of CBr3 to a double bond, and formation of symmetrical diaryl carbonates, cyclic carbonates, or carbonic-carbonic anhydrides). The parent phenols are regenerated from the O-t-Boc derivatives by the catalyst system CBr4-PPh3 without affecting other protecting groups (aryl alkyl ether, alkyl ester, and thioacetal) or competitive side reaction such as bromination, nitrene (from NO2) and α,α-dibromoolefine (with CHO/COMe) formation, and transesterification (with CO2Me/Et) taking place.

Triphenylphosphine as a novel organocatalyst for chemoselective O-tert-butoxycarbonylation of phenols

A novel organocatalytic procedure for the chemoselective O-tert-butoxycarbonylation of phenols under neutral and neat conditions is described. Georg Thieme Verlag Stuttgart.

Strategies for the preparation of differentially protected ortho-prenylated phenols

A new process for ortho-prenylation of phenols is presented within the context of known methods. All of the processes are briefly assessed with regards to the substitution patterns and accompanying functional groups tolerated by each strategy. The conclus

A mild anionic method for generating o-quinone methides: Facile preparations of ortho-functionalized phenols

A low-temperature method for generating o-quinone methides is described which permits facile introduction of assorted R substituents onto the aryl ring system at low temperature. The method is useful for the efficient preparation of ortho-ring-alkylated phenols.