346433-97-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-fluoro-5-nitroaniline serves as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-4-fluoro-5-nitroaniline is utilized in the production of pesticides and other agrochemicals. Its reactivity and chemical properties make it a valuable intermediate for creating effective and targeted agricultural products.
Used in Organic Chemistry Research:
2-Bromo-4-fluoro-5-nitroaniline is also employed as a research compound in organic chemistry. Its distinct characteristics facilitate studies on chemical reactions and mechanisms, furthering scientific understanding and innovation in the field.
Used in Dye and Pigment Production:
2-Bromo-4-fluoro-5-nitroaniline is used as an intermediate in the production of dyes and pigments. Its ability to form various chemical bonds makes it suitable for creating a wide range of colorants used in different industries, including textiles, plastics, and printing.

Upstream product

• 1003-98-1 2-bromo-4-fluoroaniline 

Downstream Products

• 1309833-21-3 2-Cyclopropyl-4-fluoro-5-nitroaniline 
• 1356493-38-3 N₂-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine 
• 1356493-73-6 4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine 
• 1356493-70-3 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-5-isopropyl-1H-tetrazole 
• 1356493-67-8 N-(2-cyclopropyl-4-fluoro-5-nitrophenyl)isobutyramide 
• 1356493-39-4 4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)-2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)pyrimidine-5-carbonitrile 
• 1356493-61-2 1-(4-fluoro-5-nitro-2-(prop-1-en-2-yl)phenyl)-1H-tetrazole 
• 1356493-60-1 2-fluoro-4-isopropyl-5-(1H-tetrazol-1-yl)benzenamine 
• 1356493-51-0 4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine 
• 1356493-50-9 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-1H-tetrazole 
• 1356493-43-0 N₂-(4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)phenyl)-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine 
• 1356493-36-1 2-(2-fluoro-4-isopropyl-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

Amino pyrimidine compound and preparation method and application thereof

The invention relates to an amino pyrimidine compound and a preparation method and application thereof. The amino pyrimidine compound has a structure as shown in a formula I. The formula is shown in the description. The compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The invention further relates to a medicine composition comprising the compound, a preparation methodand application thereof in preparation of anti-tumor medicines.

PROTEIN KINASE C INHIBITORS AND USES THEREOF

This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

PROTEIN KINASE C INHIBITORS AND USES THEREOF

This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Design and syntheses of novel N -(benzothiazol-5-yl)-4,5,6,7-tetrahydro-1 H -isoindole-1,3(2 H)-dione and N -(benzothiazol-5-yl)isoindoline-1,3-dione as potent protoporphyrinogen oxidase inhibitors

Discovery of protoporphyrinogen oxidase (PPO, EC 1.3.3.4) inhibitors has been one of the hottest research areas in the field of herbicide development for many years. As a continuation of our research work on the development of new PPO-inhibiting herbicides, a series of novel N-(benzothiazol-5-yl)-4,5,6,7- tetrahydro-1H-isoindole-1,3(2H)-diones (1a-p) and N-(benzothiazol-5-yl) isoindoline-1,3-diones (2a-h) were designed and synthesized according to the ring-closing strategy of two ortho-substituents. The bioassay results indicated that some newly synthesized compounds exhibited higher PPO inhibition activity than the control of sulfentrazone. Compound 1a, S-(5-(1,3-dioxo-4,5,6,7- tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl) O-methyl carbonothioate, was identified as the most potent inhibitor with ki value of 0.08 μM, about 9 times higher than that of sulfentrazone (k i = 0.72 μM). Further green house assay showed that compound 1b, methyl 2-((5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6- fluorobenzothiazol-2-yl)thio)acetate, exhibited herbicidal activity comparable to that of sulfentrazone even at a concentration of 37.5 g ai/ha. In addition, among six tested crops, wheat exhibited high tolerance to compound 1b even at a dosage of 300 g ai/ha. These results indicated that compound 1b might have the potential to be developed as a new herbicide for weed control of wheat field.