346436-53-1

Upstream product

• 2698-42-2 2-(2-bromobenzylidene)malononitrile 
• 126-81-8 dimedone 
• 6630-33-7 ortho-bromobenzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Magnetized melamine-modified polyacrylonitrile (PAN@melamine/Fe3O4) organometallic nanomaterial: Preparation, characterization, and application as a multifunctional catalyst in the synthesis of bioactive dihydropyrano [2,3-c]pyrazole

An efficient magnetic polymer-based nanomaterial was prepared in three main steps including synthesis of polyacrylonitrile (PAN), modification of PAN with melamine, and magnetization of the PAN@melamine compound by in situ construction of Fe3O

Nickel ferrite (NiFe2O4) nanoparticles as magnetically recyclable nanocatalyst for highly efficient synthesis of 4H-chromene derivatives

An adapted one-pot route to nanocatalyst-assisted synthesis of 4H-chromenes via three component condensation reaction between dimedone, malononitrile, and a broad range of aryl aldehydes by the use of magnetic nickel ferrite nanoparticles is described. By this achievement, not only a novel route to highly efficient synthesis of these series of heterocycles was introduced but also the scope of these medicinally important IP: 127.0.0.1 productsOn: wasFri, developed 10 Jan 2020 via preparation 23:24:53 of some novel products. Above all, a new application Copyright: of nickel ferrite American nanoparticles Scientific(NiFe Publishers 2O4 NPs) as highly efficient, green and magnetically recyclable catalyst has Delivered been introduced. by Ingenta Overall, obtaining good to excellent yields of products, environmentally and economic benign procedure, easy handling, availability of starting materials, use of non-toxic solvents, and high recyclability of nano-catalyst could be countered as most important advantages of this methodology.

MCM-41@Schiff base-Co(OAc)2 as an efficient catalyst for the synthesis of pyran derivatives

Heterogeneous ordered mesoporous silica materials catalyst, MCM-41@Schiff base-Co(AcO)2, reveals high catalytic performance within the synthesis of pyran derivatives using the multicomponent reaction of aldehydes, malononitrile and 2-naphthol (

Preparation and characterization of an eco-friendly ZnFe2O4@alginic acid nanocomposite catalyst and its application in the synthesis of 2-amino-3-cyano-4H-pyran derivatives

Alginic acid as a linear polysaccharide derived from natural resources can be used in the role of a green catalyst in organic reactions. Properties such as reactivity, renewability and biodegradability make this polysaccharide as an eco-friendly organocat

Efficient synthesis of 2-amino-3-cyano-4H-pyran derivatives via a non-catalytic one-pot three-component reaction

Abstract: A convenient one-pot multi-component strategy was conducted successfully under catalyst-free conditions employing water and PEG-400 as the efficient and cheap promoting medium. Three types and nearly 50 2-amino-3-cyano-4H-pyran annulated derivat

Organocatalyzed Enantioselective Synthesis of 2-Amino-4H-chromene Derivatives

Optically active 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylates, 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles, and 2-amino-8-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles were synthesized. Using cinchona alkaloid-derived bifunctional catalysts, the corresponding 2-amino-4H-chromene derivatives were obtained in high yields and moderate to high ee values (up to 82% ee) from the tandem Michael addition–cyclization reaction between 1,3-cyclohexanediones or 1,2-cyclohexanediones and (E)-3-aryl-2-cyanoacrylate or alkylidene malononitrile derivatives.

Amine-functionalized hyper-crosslinked polyphenanthrene as a metal-free catalyst for the synthesis of 2-amino-tetrahydro-4H-chromene and pyran derivatives

The hyper-crosslinked microporous polyphenanthrene spheres were fabricated simply by the polymerization of phenanthrene using bromomethyl methyl ether as a bridging agent in the absence of any templates. The organic spheres were subjected to amine-functionalizing on the periphery of them using unreacted bromomethyl groups. The amine-functionalized microporous polyphenthrene could be employed as a highly effective and stable solid basic catalyst for the syntheses of functionalized 2-amino-tetrahydro-4H-chromene and pyran derivatives. The significant features of these reactions are high product yields, environmental benignity, short reaction time, broad substrate scope, and non-requirement of toxic solvents. Furthermore, the catalyst can be reused up to four times without significant loss of activity.

Cheap thiamine hydrochloride as efficient catalyst for synthesis of 4H-benzo[b]pyrans in aqueous ethanol

Preparation of pharmaceutically active 2-amino-4H-pyran derivatives has been achieved using cheap thiamine hydrochloride as catalyst. A wide range of aromatic aldehydes easily undergo condensation with malononitrile and several kinds of 1,3-cyclohexanedio

Sodium ethylene diamine tetraacetate catalyzed synthesis of chromene derivatives via multi-component reactions at low catalyst loading

An efficient and practical protocol for the synthesis of chromenes derivatives catalyzed by a low-loading sodium ethylene diamine tetraacetate (2?mol%) as a catalyst via multicomponent reaction is reported. A wide range of aromatic aldehydes easily underg

Efficient and green synthesis of 4H-pyran derivatives under ultrasound irradiation in the presence of K2CO3 supported on acidic montmorillonite

Acid-treated montmorillonite coating with K2CO3 is used as a catalyst for an efficient, rapid, one-pot synthesis of 4H-pyran derivatives in good yield under ultrasonic irradiation. The catalyst is environmentally benign, easy handlin