346441-03-0

Upstream product

• 346441-02-9 3-[(R)-2-benzyloxycarbonylamino-(dimethylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid benzyl ester 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 354117-18-3 (2R,3aS,8aS)-3,3a,8,8a-tetrahydro-2H-pyrrolo[2,3-b]indole-1,2-dicarboxylic acid 2-allyl ester 1-benzyl ester 
• 346440-85-5 (R)-2-benzyloxycarbonylamino-3-(1H-indol-3-yl)propionic acid allyl ester 
• 354117-19-4 (2R,3aS,8aS)-3,3a,8,8a-tetrahydro-2H-pyrrolo[2,3-b]indole-1,2-dicarboxylic acid 2-allyl ester 1-benzyl ester 
• 346441-01-8 3-((S)-2-benzyloxycarbonylamino-carboxy-(dimethylamino)-propyl)-indole-1-carboxylic acid benzyl ester 
• 346441-00-7 3-((S)-2-allyloxycarbonyl-2-benzyloxycarbonylamino-(dimethylamino)-propyl)-indole-1-carboxylic acid benzyl ester 
• 354117-25-2 (2S,3aS,8aR)-2-dimethylaminomethyl-2,3,3a,8a-tetrahydro-pyrrolo[2,3-b]indole-1,2,8-tricarboxylic acid 2-allyl ester 1,8-dibenzyl ester 
• 2279-15-4 N-(benzyloxycarbonyl)-D-tryptophan 

Relevant academic research and scientific papers

Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK1 receptor antagonist

This paper describes the synthesis and physical and biological effects of introducing different substituents at the α-position of the tryptophan containing neurokinin-1 receptor antagonist [(R)-2-(1H-indol-3-yl)-1-methyl-1-((S)-1 -phenyl-ethylcarbamoyl)-e