34658-62-3Relevant academic research and scientific papers
Method for synthesizing N - substituted hydantoin compounds (by machine translation)
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Paragraph 0063-0068, (2020/11/22)
The invention discloses a synthetic method of N - substituted hydantoin compounds, which comprises the following steps: taking an acyl azide compound shown as a formula I and a glycine ethyl ester compound as shown in a formula II as a raw material, carrying out heating reaction under the presence of an additive to obtain N - substituted hydantoin compounds as shown in formula III. In the formula, R1 And R2 Independently selected from hydrocarbyl, substituted hydrocarbyl, aryl, substituted aryl or aralkyl; R2 Selected from hydrocarbyl or aryl; R3 Selected from a hydrogen atom and a hydrocarbyl group. To the synthesis method, the functionalized N - substituted hydantoin compounds can be efficiently synthesized, the synthesis steps are few, the conditions are mild, the operation is safe, the raw materials are nontoxic, cheap and easily available, and the synthesis method has the N - substituted hydantoin compounds with the nitrogen heterocyclic skeleton with novel structure, the yield can reach 92%, the purity is 99%, and industrial synthesis is easy. (by machine translation)
Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization/cleavage step
Dressman,Spangle,Kaldor
, p. 937 - 940 (2007/10/03)
An 800 compound hydantoin library has been constructed using a diverse set of 20 amino acids and over 80 primary amines. Amino acids were attached via their N-termini to hydroxymethyl polystyrene using a carbamate linker. Bound amino acids were converted to their corresponding amides and then cyclized under basic conditions to give hydantoins in high purities.
