34658-69-0Relevant academic research and scientific papers
Method of preparing 2-(phenylamino)-imidazolines-(2)
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, (2008/06/13)
A process for preparing compounds of the formula: STR1 or pharmaceutically acceptable salts thereof, wherein R1 and R2 each individually are hydrogen, halogen, or nitro, which comprises the steps of: (a) alkylating a compound of the formula: STR2 wherein R3 is C1 to C4 alkyl or phenyl, with a compound of the formula: wherein R4 is C1 to C6 alkyl or phenyl-alkyl where the alkyl is C1 to C4 and X is halogen, in the presence of a base to yield a compound of the formula: STR3 and; (b) cyclizing the compound formed during step (a) with ethylenediamine mono-p-toluenesulphonate at a temperature of 100° to 200° C. to yield the desired product. New intermediate compounds are also disclosed. The desired products have antihypertensive properties.
