346599-80-2 Usage
Molecular structure
Contains a pyrrole ring, a propanoic acid group, and a pyrrolopyrimidine moiety.
Chemical classification
Is a chemical compound.
Enzyme inhibition
Is a potent and selective inhibitor of Janus kinase 1 (JAK1).
Biological role
Involved in the regulation of the immune system and the inflammatory response.
Potential applications
In the treatment of autoimmune diseases (e.g. rheumatoid arthritis, inflammatory bowel disease) and certain types of cancer.
Drug development
Its chemical structure and properties make it a promising candidate for the development of new drugs targeting JAK1-mediated pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 346599-80-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,6,5,9 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 346599-80:
(8*3)+(7*4)+(6*6)+(5*5)+(4*9)+(3*9)+(2*8)+(1*0)=192
192 % 10 = 2
So 346599-80-2 is a valid CAS Registry Number.
346599-80-2Relevant academic research and scientific papers
4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
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, (2008/06/13)
This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed herein are of Formula 1 and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, X, Y, and Z are defined herein. The invention fuirther relates to pharmaceutical compositions and dosage forms comprising compounds of Formula 1 and to methods of their use for the treatment and/or prevention of diseases such as, but not limited to, cancer.
