346599-89-1

Basic information

• Product Name: 1H-Pyrrole-3-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3- d]pyrimidin-5-ylidene]methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-
• CAS NO: 346599-89-1
• Molecular Formula: C26H29ClFN7O2
• Molecular Weight: 526.013
• Mol File: 346599-89-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3- d]pyrimidin-5-ylidene]methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3- d]pyrimidin-5-ylidene]methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-(346599-89-1)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3- d]pyrimidin-5-ylidene]methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-(346599-89-1)

Safety Data

• Hazardous Substances Data: 346599-89-1(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 356068-86-5 N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 
• 346600-16-6 4-(3-chloro-4-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one 

Relevant articles and documents

4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors

This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed herein are of Formula 1 and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, X, Y, and Z are defined herein. The invention fuirther relates to pharmaceutical compositions and dosage forms comprising compounds of Formula 1 and to methods of their use for the treatment and/or prevention of diseases such as, but not limited to, cancer.