346600-12-2

Basic information

• Product Name: {5-[4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-6-OXO-6,7-DIHYDRO-PYRROLO [2,3-D]PYRIMIDIN-5-YLIDENEMETHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL}-ACETIC ACID
• CAS NO: 346600-12-2
• Molecular Weight: 441.849
• Mol File: 346600-12-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {5-[4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-6-OXO-6,7-DIHYDRO-PYRROLO [2,3-D]PYRIMIDIN-5-YLIDENEMETHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL}-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: {5-[4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-6-OXO-6,7-DIHYDRO-PYRROLO [2,3-D]PYRIMIDIN-5-YLIDENEMETHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL}-ACETIC ACID(346600-12-2)
• EPA Substance Registry System: {5-[4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-6-OXO-6,7-DIHYDRO-PYRROLO [2,3-D]PYRIMIDIN-5-YLIDENEMETHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL}-ACETIC ACID(346600-12-2)

Safety Data

• Hazardous Substances Data: 346600-12-2(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 52513-48-1 2-(5-formyl-2,4-dimethyl-1H-pyrrol-3-yl)acetic acid 
• 346600-16-6 4-(3-chloro-4-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one 

Relevant articles and documents

4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors

This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed herein are of Formula 1 and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, X, Y, and Z are defined herein. The invention fuirther relates to pharmaceutical compositions and dosage forms comprising compounds of Formula 1 and to methods of their use for the treatment and/or prevention of diseases such as, but not limited to, cancer.