34662-30-1

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-5-nitrobenzonitrile is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Chloro-5-nitrobenzonitrile serves as a crucial component in the production of pesticides and other crop protection agents. Its incorporation enhances the effectiveness of these products in controlling pests and diseases.
Used in Dye Production:
3-Chloro-5-nitrobenzonitrile is used as a starting material for the synthesis of various dyes. Its chemical properties contribute to the creation of dyes with specific color characteristics and improved performance in different applications.
Used in Fine Chemicals Industry:
As a versatile building block, 3-Chloro-5-nitrobenzonitrile is utilized in the production of a wide range of fine chemicals. Its presence in these compounds allows for the development of specialty chemicals with unique properties and applications in various industries.

InChI:InChI=1/C7H3ClN2O2/c8-6-1-5(4-9)2-7(3-6)10(11)12/h1-3H

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 1212021-11-8 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 20352-84-5 1-amino-2-cyano-4-nitro-6-chlorobenzene 

Downstream Products

• 34662-36-7 3-chloro-5-nitrobenzoic acid 
• 53312-78-0 3-amino-5-chloro-benzonitrile 

Relevant academic research and scientific papers

meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C?H Borylation

Herein, we report the meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C?H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes in a one-pot fashion. This protocol allows the synthesis of meta-nitrated arenes that are tedious to prepare or require multistep synthesis using the existing methods. The reaction tolerates a wide array of ortho/para-directing groups, such as ?F, ?Cl, ?Br, ?CH3, ?Et, ?iPr ?OCH3, and ?OCF3. It also provides regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives. The application of this method is demonstrated in the late-stage modification of complex molecules and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, we have shown that the nitro product obtained by this strategy can also be directly converted to the aniline or hindered amine through Baran's amination protocol.

Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus

Inhibition of the protein chaperone Hsp90 is a promising new approach to cancer therapy. We describe the preparation of potent non-benzoquinone ansamycins. One of these analogues, generated by feeding 3-amino-5-chlorobenzoic acid to a genetically engineer

Macrolactams by engineered biosynthesis

Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynt

Aminoacetamide acyl guanidines as beta-secretase inhibitors

There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R25, R26 and R27 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.