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346664-99-1

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346664-99-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 346664-99-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,6,6,6 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 346664-99:
(8*3)+(7*4)+(6*6)+(5*6)+(4*6)+(3*4)+(2*9)+(1*9)=181
181 % 10 = 1
So 346664-99-1 is a valid CAS Registry Number.

346664-99-1Downstream Products

346664-99-1Relevant articles and documents

N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: The development of diaryl amino piperidines as potent δ opioid receptor agonists with in vivo anti-nociceptive activity in rodent models

Jones, Paul,Griffin, Andrew M.,Gawell, Lars,Lavoie, Rico,Delorme, Daniel,Roberts, Edward,Brown, William,Walpole, Christopher,Xiao, Wenhau,Boulet, Jamie,Labarre, Maryse,Coupal, Martin,Butterworth, Joanne,St-Onge, Stephane,Hodzic, Lejla,Salois, Dominic

scheme or table, p. 5994 - 5998 (2010/05/18)

We have investigated a series of phenolic diaryl amino piperidine delta opioid receptor agonists, establishing the importance of the phenol functional group and substitution on the piperdine nitrogen for delta agonist activity and selectivity versus the mu and kappa opioid receptors. This study uncovered compounds with improved agonist potency and selectivity compared to the standard, non-peptidic delta agonist SNC-80. In vivo anti-nociceptive activity of analog 8e in two rodent models is discussed, demonstrating the potential of delta agonists to provide a novel mechanism for pain relief.

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