346664-99-1

Basic information

• Product Name: N,N-diethyl-4-[[1-(3-furanylmethyl)-4-piperidinyl](3-hydroxyphenyl)amino]-benzamide
• CAS NO: 346664-99-1
• Molecular Weight: 447.577
• Mol File: 346664-99-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-4-[[1-(3-furanylmethyl)-4-piperidinyl](3-hydroxyphenyl)amino]-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-4-[[1-(3-furanylmethyl)-4-piperidinyl](3-hydroxyphenyl)amino]-benzamide(346664-99-1)
• EPA Substance Registry System: N,N-diethyl-4-[[1-(3-furanylmethyl)-4-piperidinyl](3-hydroxyphenyl)amino]-benzamide(346664-99-1)

Safety Data

• Hazardous Substances Data: 346664-99-1(Hazardous Substances Data)

Upstream product

• 346664-90-2 N,N-diethyl-4-[[1(3-furanylmethyl)-4-piperidinyl](3-methoxyphenyl)amino]-benzamide 

Relevant articles and documents

N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: The development of diaryl amino piperidines as potent δ opioid receptor agonists with in vivo anti-nociceptive activity in rodent models

We have investigated a series of phenolic diaryl amino piperidine delta opioid receptor agonists, establishing the importance of the phenol functional group and substitution on the piperdine nitrogen for delta agonist activity and selectivity versus the mu and kappa opioid receptors. This study uncovered compounds with improved agonist potency and selectivity compared to the standard, non-peptidic delta agonist SNC-80. In vivo anti-nociceptive activity of analog 8e in two rodent models is discussed, demonstrating the potential of delta agonists to provide a novel mechanism for pain relief.