346669-97-4

Basic information

• Product Name: N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid α-N-{(4R)-5-(benzyloxymethoxy)-4-[(R)-3-benzyloxytetradecanoylamino]pentyl}amide β-benzyl ester
• Synonyms: N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid α-N-{(4R)-5-(benzyloxymethoxy)-4-[(R)-3-benzyloxytetradecanoylamino]pentyl}amide β-benzyl ester
• CAS NO: 346669-97-4
• Molecular Weight: 1168.69
• Mol File: 346669-97-4.mol

Chemical Properties

• CAS DataBase Reference: N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid α-N-{(4R)-5-(benzyloxymethoxy)-4-[(R)-3-benzyloxytetradecanoylamino]pentyl}amide β-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid α-N-{(4R)-5-(benzyloxymethoxy)-4-[(R)-3-benzyloxytetradecanoylamino]pentyl}amide β-benzyl ester(346669-97-4)
• EPA Substance Registry System: N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid α-N-{(4R)-5-(benzyloxymethoxy)-4-[(R)-3-benzyloxytetradecanoylamino]pentyl}amide β-benzyl ester(346669-97-4)

Safety Data

• Hazardous Substances Data: 346669-97-4(Hazardous Substances Data)

Upstream product

• 88862-84-4 3-hydroxy-D-tetradecanoic acid benzyl ester 
• 28715-21-1 (R)-3-hydroxytetradecanoic acid 
• 3587-60-8 Benzyloxymethyl chloride 
• 346669-95-2 (2R)-5-(benzyloxycarbonylamino)-2-[(R)-3-benzyloxytetradecanoylamino]pentan-1-ol benzyloxymethyl ether 
• 253586-97-9 (2R)-5-benzyloxycarbonylamino-2-[(R)-3-benzyloxytetradecanoylamino]pentan-1-ol 
• 914499-86-8 benzyl (R)-3-dodecanoyloxytetradecanoate 
• 346669-96-3 (2R)-5-amino-2-[(R)-3-benzyloxytetradecanoylamino]pentan-1-ol benzyloxymethyl ether 
• 346669-80-5 N-[(R)-3-dodecanoyloxytetradecanoyl]-D-aspartic acid β-benzyl ester 
• 346669-98-5 N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester 
• 114264-01-6 methyl (R)-3-(benzyloxy)tetradecanoate 
• 87357-67-3 (R)-3-benzyloxytetradecanoic acid 
• 107856-74-6 C₂₆H₅₀O₄ 
• 76062-97-0 methyl (R)-3-hydroxytetradecanoate 

Downstream Products

• 346670-00-6 N-[(R)-3-dodecanoyloxytetradecanoyl]-L-homoserine α-N-{(4R)-5-(benzyloxymethoxy)-4-[(R)-3-benzyloxytetradecanoylamino]pentyl}amide 

Relevant articles and documents

Synthesis and immunobiological activity of an original series of acyclic lipid A mimics based on a pseudodipeptide backbone

Nδ-L-Homoserinyl-D-ornithinol pseudodipeptides N-acylated with typical Escherichia coli lipid A fatty acid residues and mono-O- or bis-O-phosphorylated have been prepared and their properties investigated. The derivatives carrying two phosphate groups were found to be inducers of NO production. In addition, while they were unable to induce significantly the production of interleukin-6 (IL-6) by human PBMC cells, these compounds behaved also as potent antagonists of LPS-induced IL-6 production in the same human cells system. In conclusion, the molecules described here are the first members of an original class of immunobiologically active lipid A mimics based on an acyclic pseudodipeptide backbone carrying only the essential functionalities of the parent lipid A structure (OM-174). As the products exhibit very low endotoxicity and pyrogenicity, this class of lipid A mimics therefore opens a new generation of immunoadjuvants that possibly could reach clinical applications.