346673-06-1

Usage

Uses

TCS 2510 is a selective agonist of EP4.

Upstream product

• 128899-30-9 (R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one 
• 346672-94-4 7-[(2R)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-oxopyrrolidin-1-yl]heptanenitrile 
• 346672-95-5 7-[(2R)-2-hydroxymethyl-5-oxopyrrolidin-1-yl]heptanenitrile 
• 346672-63-7 7-[(2R)-2-formyl-5-oxopyrrolidin-1-yl]heptanenitrile 
• 20965-27-9 7-bromo-heptanonitrile 

Relevant academic research and scientific papers

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor

Analogues of PGE2 wherein the hydroxycyclopentanone ring has been replaced by a lactam have been prepared and evaluated as ligands for the EP4 receptor. An optimized compound (19a) shows high potency and agonist efficacy at the EPsu

Use of selective EP4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension

The present invention is directed to methods for treating liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension, comprising administering to the patient in need thereof a therapeutically effective amount of a selective EP4 receptor agonist of the Formulae wherein the variables A, B, Q, ═U, and R2 for Formula l; and the variables Ar, ═M, ═N, R, W, and Z for Formula II are as defined in the specification.