34668-26-3

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Furo[2,3-b]pyridine-2-carboxylic acid is utilized as a building block in the synthesis of pharmaceuticals and agrochemicals due to its potential biological activity. Its unique structure allows for the development of new compounds with therapeutic and pesticidal properties.
Used in Anti-inflammatory Applications:
Furo[2,3-b]pyridine-2-carboxylic acid is studied for its potential as an anti-inflammatory agent, which could be beneficial in treating various inflammatory conditions and diseases.
Used in Antifungal Applications:
Furo[2,3-b]pyridine-2-carboxylic acid is also researched for its potential as an antifungal agent, which could be used to combat fungal infections and control the growth of fungi in various settings.
Used in Anti-tuberculosis Applications:
Furo[2,3-b]pyridine-2-carboxylic acid has been investigated for its potential as an anti-tuberculosis agent, offering a new avenue for the development of treatments for tuberculosis.
Used in Material Science:
Furo[2,3-b]pyridine-2-carboxylic acid has potential applications in material science, where its unique properties can be harnessed to create new materials with specific characteristics.
Used as a Fluorescent Probe in Bioimaging:
Furo[2,3-b]pyridine-2-carboxylic acid has been researched for its potential use as a fluorescent probe in bioimaging, allowing for the visualization and study of biological processes and structures at the molecular level.

Upstream product

• 34668-25-2 Ethyl furo<2,3-b>pyridine-2-carboxylate 
• 109274-95-5 2-cyanofuro<2,3-b>pyridine 
• 6562-74-9 ethyl 5-aminofuro[2,3-b]pyridine-2-carboxylate 
• 109274-93-3 Furo[2,3-b]pyridine-2-carbaldehyde oxime 
• 109274-92-2 2-formylfuro<2,3-b>pyridine 

Relevant academic research and scientific papers

Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease

The invention provides compounds of Formula I: wherein Azabicyclo is These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which α7 is known to be involved.

Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease

The invention provides compounds of Formula I: 1where in W is 2These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful to treat diseases or conditions in which α7 is known to be involved.

Furopyridines. VI. Preparation and Reactions of 2- and 3- Substituted Furopyridines

This paper describes the synthesis and chemical properties of some 2- and 3-substituted furopyridines.Reaction of ethyl 2-chloronicotinate 1 with sodium ethoxycarbonylmethoxide or 1-ethoxycarbonyl-1-ethoxide gave β-keto ester 2 or ketone 5, respectively.Ketonic hydrolysis of 2 afforded ketone 3, from which furopyridine 4 was obtained by the method Sliwa.While, 2-methyl derivative 7 was prepared from 5 by reduction, O-acetylation and the subsequent pyrolysis.Reaction of ketone 3 with methyllithium gave tertiary alcohol 8 which was O-acetylated and pyrolyzed to give 3-methyl derivative 9.Formylation of 4, via lithio intermediate, with DMF yielded 2-formyl derivative 10, from which 7, was obtained by Wolff-Kishner reduction.Dehydration of the oxime 11 of 10 gave 2-cyano derivative 12, which was hydrolyzed to give 2-carboxylic acid 13.Reaction of 3-bromo compound 14 with copper(I)cyanide gave 3-cyano derivative 15.Alkaline hydrolysis of 15 afforded compound 16 and 17, while acidic hydrolysis gave carboxamide 18.Reduction of 15 with DIBAL-H afforded 3-formyl derivative 19.Wolff-Kishner reduction of 19 gave no reduction product 9 but hydrazone 20.Reduction of tosylhydrazone 21 with sodium borohydride in methanol afforded 3-methoxymethylfuropyridine 22.