346694-40-4

Upstream product

• 244088-46-8 7-O-benzyl-25-O-methyl-26-O-t-butyldimethylsilylmonensin methyl ester 
• 244088-48-0 4-{9-benzyloxy-2-[2-ethyl-5'-(6-hydroxymethyl-6-methoxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-3'-methyl-octahydro-[2,2']bifuranyl-5-yl]-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-7-yl}-3-methoxy-2-methyl-pentanoic acid methyl ester 
• 346694-33-5 7-O-benzyl-25-O-methyl-25-formylmonensin methyl ester 
• 116278-62-7 25-O-methylmonensin methyl ester 
• 346694-21-1 6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid 
• 244088-32-2 25-O-methyl-26-O-t-butyldimethylsilylmonensin methyl ester 

Relevant academic research and scientific papers

Studies on chemical modification of monensin VIII. Synthesis of 7-O-substituted-25-carboxymonensins and their Ca2+ ion transport activity

Monensin (1), an ionophore antibiotic agent, was converted to 25-carboxymonensin (2) and 7-O-substituted-25-carboxyl derivatives (3a-d), which have two carboxyl groups at both ends of the molecule. Ca2+ ion transport activity of the dicarboxylic monensins was evaluated by the CHCl3 liquid membrane method, and 25-carboxymonensins (2 and 3a-d) were shown to transport the Ca2+ ion through the CHCl3 liquid membrane.