346694-77-7

Usage

Uses

Used in Peptide Nanotube Synthesis:
BOC-L-BETA-HOMOLYSINE(CBZ) is used as a synthetic precursor for the preparation of peptide nanotubes. These nanotubes are composed of cyclic tetra-β-peptides that incorporate polydiacetylene components, which are of significant interest in the field of nanotechnology and materials science due to their unique properties and potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, BOC-L-BETA-HOMOLYSINE(CBZ) can be utilized as a key intermediate in the development of peptide-based drugs. Its ability to form stable cyclic structures makes it a promising candidate for the design of novel therapeutic agents with improved stability, bioavailability, and target specificity.
Used in Cosmetic Industry:
BOC-L-BETA-HOMOLYSINE(CBZ) may also find applications in the cosmetic industry, where cyclic peptides are increasingly being explored for their potential as active ingredients in skincare and haircare products. These peptides can offer a range of benefits, including anti-aging, moisturizing, and protective effects, due to their ability to interact with various biological targets and modulate skin function.
Used in Research and Development:
BOC-L-BETA-HOMOLYSINE(CBZ) is an essential tool for researchers working on the development of new peptide-based materials and therapeutics. Its role in the synthesis of cyclic peptides and peptide nanotubes makes it a valuable component in the exploration of novel molecular structures and their potential applications in various fields, including medicine, biotechnology, and materials science.

Upstream product

• 172833-14-6 ((S)-5-tert-Butoxycarbonylamino-7-diazo-6-oxo-heptyl)-carbamic acid benzyl ester 
• 2389-45-9 Boc-Lys(Z)-OH 
• 153074-94-3 (S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-heptanoic acid methyl ester 

Relevant academic research and scientific papers

Exceptionally simple homologation of protected α- to β-amino acids in the presence of silica gel

The Wolff rearrangement of α-amino acid-derived diazoketones is simply achieved by gentle warming in a ethyl acetate/silica gel slurry containing catalytic amounts of silver trifluoroacetate. Without workup (not counting filtration and evaporation) the pr

Synthesis of optically active β-amino acid N-carboxyanhydrides

(Equation presented) Methodology has been developed for the general synthesis of optically active β-amino acid N-carboxyanhydrides (β-NCAs) through cyclization of Nβ-Boc or Nβ-Cbz β-amino acids using phosphorus tribromide. The format

2,2'-dithiobisbenzamides derived from α-, β- and γ-amino acids possessing anti-HIV activities: Synthesis and structure-activity relationship

Nucleocapsid protein (NCp7), which contains highly conserved retroviral zinc fingers, is essential in the early as well as the late phase of human immunodeficiency virus (HIV) life cycle and constitutes a novel target for AIDS therapy. HIV-1 NCp7 is a basic 55 amino acid protein containing two C(X)2C(X)4H(X)4C motif zinc fingers flanked by basic amino acids on each side. 2,2'-dithiobisbenzamides have previously been reported to release zinc from these NCp7 zinc fingers and also to inhibit HIV replication. Specifically, 2,2'-dithiobisbenzamides derived from simple amino acids showed good antiviral activities. The benzisothiazolone 3, the cyclic derivative of 2, was selected for clinical trials as an agent for AIDS therapy. Herein we report the syntheses and antiviral activities, including therapeutic indices, of 2,2'-dithiobisbenzamides derived from α-, β- and γ-amino acids. Electrospray ionization mass spectrometry was used to study the zinc-ejection activity of these compounds. Among the α-amino acid derived 2,2'-dithiobisbenzamides, analogues containing alkyl side chains were found to be antivirally active with good therapeutic indices. 2,2'-Dithiobisbenzamides, derived from β- and γ-amino acids, were found to possess better antiviral and therapeutic efficacies than the α-amino acid analogues. Thus compound 59 was found to possess an EC50 of 1.9μM with a therapeutic index of >50. Interestingly, 2,2'-dithiobisbenzamides derived from α-amino acids containing a protected acid function and polar side chains also exhibited very good antiviral activity. Copyright (C) 1998 Elsevier Science Ltd.