346727-55-7

Basic information

• Product Name: C₂₁⁽¹¹⁾CH₂₆NO₃⁽¹⁺⁾*I^(1-)
• Synonyms: C₂₁⁽¹¹⁾CH₂₆NO₃⁽¹⁺⁾*I^(1-)
• CAS NO: 346727-55-7
• Molecular Weight: 478.347
• Mol File: 346727-55-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁⁽¹¹⁾CH₂₆NO₃⁽¹⁺⁾*I^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁⁽¹¹⁾CH₂₆NO₃⁽¹⁺⁾*I^(1-)(346727-55-7)
• EPA Substance Registry System: C₂₁⁽¹¹⁾CH₂₆NO₃⁽¹⁺⁾*I^(1-)(346727-55-7)

Safety Data

• Hazardous Substances Data: 346727-55-7(Hazardous Substances Data)

Upstream product

• 54245-42-0 [11C]methyl iodide 
• 6581-06-2 quinuclidinyl benzilate 

Relevant articles and documents

Facile and improved synthesis of [11C]Me-QNB

[11C]Me-QNB is a muscarinic acetylcholinergic receptor antagonist that has been used for the assessment of myocardial muscarinic receptors density in different cardiovascular pathologies. In the current technical note, we report a facile, highly efficient and fully automated method for the preparation of this radiotracer. The radiosynthesis was performed by reaction of [11C]CH3I with the desmethylated precursor (QNB) at room temperature using the captive solvent method. Excellent radiochemical yield (91.1 ± 2.4%, decay-corrected) and radiochemical purity (>99.5%), and good specific activity (137 ± 5 GBq/μmol) were obtained when the purification was performed by reverse phase HPLC in overall synthesis time 95%) but higher specific activity (244 ± 18 GBq/μmol) in shorter reaction times (a vial and the purification step was based on ionic chromatography.