34684-19-0

Usage

Uses

Used in Polymer and Plastics Industry:
1,2-Cyclohexanedicarbonyl dichloride (9CI) is used as a monomer for the production of polymers and plastics. Its reactive nature allows it to undergo various chemical reactions, making it a valuable component in the synthesis of these materials.
Used in Pharmaceutical Industry:
1,2-Cyclohexanedicarbonyl dichloride (9CI) is used as an intermediate in the manufacturing of pharmaceuticals. Its ability to undergo nucleophilic substitution and condensation reactions with amines and alcohols makes it a useful building block for the synthesis of various drug compounds.
Used in Agrochemical Industry:
1,2-Cyclohexanedicarbonyl dichloride (9CI) is used as an intermediate in the production of agrochemicals. Its reactivity and ability to participate in chemical reactions contribute to the development of effective agricultural chemicals.
Used in Specialty Chemicals Industry:
1,2-Cyclohexanedicarbonyl dichloride (9CI) is used as an intermediate in the manufacturing of specialty chemicals. Its versatility in chemical reactions allows it to be incorporated into a wide range of specialized chemical products.
Safety Precautions:
1,2-Cyclohexanedicarbonyl dichloride (9CI) is considered hazardous, and proper safety precautions should be taken when handling and storing this chemical. It is essential to follow all safety guidelines and regulations to minimize the risk of exposure and potential harm.

Upstream product

• 1687-30-5 cyclohexane-1,2-dicarboxylic acid 
• 2305-32-0 trans-1,2-cyclohexanedicarboxylic acid 

Downstream Products

• 115720-23-5 (+/-)-trans-1-cyano-cyclohexane-carboxylic acid-(2) 
• 104722-26-1 trans-1,2-dibenzoylcyclohexane 
• 90682-77-2 (3E,9E)-1,2-Diphenyl-3,10-bis-trimethylsilanyloxy-1,2,5,6,7,8-hexahydro-[1,2]diphosphecine 

Relevant academic research and scientific papers

Novel bivalent securinine mimetics as topoisomerase I inhibitors

A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitory activity three times that of parent securinine. Comprehensive structure-activity relationship analyses in combination with docking studies were used to rationalize the potent activity of these bivalent mimetics. Mechanistic studies served to confirm the deductions arising from docking studies that the active bivalent mimetics not only inhibited complexation between Topo I and DNA but also stabilized the Topo I-DNA complex itself.

Rational tuning chelate size of bis-oxazoline ligands to improve enantioselectivity in the asymmetric aziridination of chalcones

Chalcones were asymmetrically aziridinated with [N-(p-toluenesulfonyl) imino]phenyliodinane (PhI=NTs) as a nitrene source under catalysis of CuOTf and a series of cyclohexane-linked bis-oxazolines (cHBOXes), which are chelate size rationally tuned bis-oxazolines. The results indicate that highly enantioselective aziridination of chalcones with up to >99% ee have been achieved under catalysis of (S,S)-1,2-bis[(S)-(4-phenyl)oxazolin-2-yl] cyclohexane, which is the most-matched stereoisomer among cyclohexane-linked bis-oxazolines. It was also found that the enantioselectivity is not substituent-dependent with respect to chalcones in the present case, unlike with 1,8-anthracene-linked bis-oxazolines (AnBOXes).