3469-08-7

Basic information

• Product Name: 5-METHOXY-1H-INDENE
• Synonyms: 5-METHOXY-1H-INDENE;6-Methoxy-1H-indene
• CAS NO: 3469-08-7
• Molecular Formula: C₁₀H₁₀O
• Molecular Weight: 146.1858
• Mol File: 3469-08-7.mol

Chemical Properties

• Boiling Point: 220-240 °C
• Appearance: /
• Density: 1.076±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-METHOXY-1H-INDENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-1H-INDENE(3469-08-7)
• EPA Substance Registry System: 5-METHOXY-1H-INDENE(3469-08-7)

Safety Data

• Hazardous Substances Data: 3469-08-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Methoxy-1H-indene is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs and medicinal compounds.
Used in Fragrance Industry:
In the fragrance industry, 5-Methoxy-1H-indene is utilized as a component in creating unique scents and perfumes, capitalizing on its chemical properties to enhance the olfactory profile of products.
Used in Specialty Chemicals:
5-Methoxy-1H-indene is employed in the production of specialty chemicals, where its distinctive structure and reactivity are leveraged to create compounds with specific applications in various industries.
Safety Considerations:
It is crucial to handle 5-Methoxy-1H-indene with care due to its potential harmful effects if ingested, inhaled, or in contact with skin. Appropriate safety measures, including the use of personal protective equipment and adherence to proper handling protocols, should be implemented when working with this chemical.

Upstream product

• 5111-69-3 5-methoxyindane 

Downstream Products

• 68294-03-1 2-(carboxymethyl)-4-methoxybenzoic acid 
• 753020-50-7 5-methoxy-cis-1,2-indandiol 
• 469904-27-6 5-methoxyindene 1,2-oxide 
• 753020-50-7 5-methoxy-trans-1,2-indandiol 
• 1359938-25-2 C₂₁H₂₃NO 
• 1359938-26-3 C₂₈H₂₉NO 
• 1359938-27-4 C₂₁H₂₅NO 
• 1359938-28-5 C₂₈H₃₁NO 

Relevant articles and documents

AuCl3-Catalyzed Ring-Closing Carbonyl–Olefin Metathesis

Compared with the ripeness of olefin metathesis, exploration of the construction of carbon–carbon double bonds through the catalytic carbonyl–olefin metathesis reaction remains stagnant and has received scant attention. Herein, a highly efficient AuCl3-catalyzed intramolecular ring-closing carbonyl–olefin metathesis reaction is described. This method features easily accessible starting materials, simple operation, good functional-group tolerance and short reaction times, and provides the target cyclopentenes, polycycles, benzocarbocycles, and N-heterocycle derivatives in good to excellent yields.

TiO2-sensitised photo-oxidation mechanism of indane and some of its hetero-analogues in deaerated CH3CN

A mechanistic study, principally based on product analysis, relative to the TiO2-photosensitized oxidation of indane and some of its hetero-analogues, in deaerated CH3CN and in the presence of Ag 2SO4, was performed. In particular: (i) 1-acetamidoindan (principal product), indene, 1-indanol and 1-indanone were obtained from indan; (ii) 5-methoxyindan gave 6-methoxyindene (principal product) and 5-methoxy-1-indanone; (iii) 2,3-dihydrobenzofuran, 2,3-dihydroindole and 2,3-dihydrobenzothiophene produced benzofuran, indole and benzothiophen (the last one accompanied by minor amounts of 2,3-dihydrobenzothiophene-1-oxide), respectively. Considering the previous studies on photo-oxidation of analogous substrates as benzylic derivatives (arenes, alcohols and ethers) and from reaction product profiles, an electron-transfer mechanism (from the substrate to the photogenerated hole) is suggested, where the radical cation intermediate should deprotonate to a benzylic radical. The carbocation obtained from the oxidation of this radical should competitively evolve to alkene, alcohol and acetamide. H218O labelling photo-oxidation experiments suggest that the ketone, when present, should derive from the substrate, through the alcohol as intermediate. Copyright