34707-82-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(pyridin-2-yl)-1-[2-(pyridin-4-yl)ethyl]-1H-benzimidazole is used as a potential pharmaceutical agent for its potential anticancer, antiviral, and anti-inflammatory properties. Its unique structure may contribute to its effectiveness in treating various diseases and conditions, making it a promising candidate for further research and development in the field of medicinal chemistry.

Upstream product

• 100-43-6 4-vinylpyridine 
• 1137-68-4 2-(2'-pyridyl)benzimidazole 
• 95-54-5 1,2-diamino-benzene 
• 109-06-8 α-picoline 

Downstream Products

• 1137-68-4 2-(2'-pyridyl)benzimidazole 

Relevant academic research and scientific papers

ACIDIC PROPERTIES OF BENZIMIDAZOLES AND SUBSTITUENT EFFECTS. V. PROTECTION OF BENZIMIDAZOLES BY N-ALKYL BOND FORMATION USING VINYLPYRIDINES

Vinylpyridines were utilized for protection of the benzimidazole N-H bond to give 1-(2-pyridylethyl)-benzimidazoles.The reaction was found to progress smoothly when glacial acetic acid was used as a catalyst.In the alkylation of 5- or 7-substituted-2-arylbenzimidazoles with vinylpyridines, the yield decreased with increasing electron-attracting effect of the substituent groups in the benzimidazole ring.On the other hand, the removal of pyridylethyl groups by the use of aluminum chloride as a catalyst was kinetically examined; a large excess of sodium hydroxide was used for decomposition of the intermediate adduct of aluminum chloride.The rate increased somewhat when electron-releasing substituent groups were present in the benzimidazole ring. 1--2-arylbenzimidazoles were resistant to removal of their (2-pyridyl)ethyl groups. 4-Vinylpyridine can be used more efficiently as a protecting agent.Keywords: 2-pyridylbenzimidazoles; protection with vinylpyridines for imidazole; 1-(2-pyridylethyl)-benzimidazoles; substituent effect on N-alkylation of benzimidazoles; rate of removal of pyridylethyl groups by aluminum chloride catalyst