3471-13-4

Upstream product

• 65466-78-6 2-(methylphenyltelluranylidene)dimedon 
• 126-81-8 dimedone 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 105244-30-2 2-(3,3-Bis-dimethylamino-allylidene)-5,5-dimethyl-cyclohexane-1,3-dione 
• 107-91-5 cyanoacetic acid amide 
• 7357-70-2 Cyanothioacetamide 

Downstream Products

• 70092-97-6 4-Iodo-benzoic acid [3-hydroxy-5,5-dimethyl-cyclohex-2-en-(Z)-ylidene]-hydrazide 
• 70093-09-3 5,5-Dimethyl-3-hydroxy-2-cyclohexenon-1-gluconylhydrazon 
• 53696-31-4 2-(5,5-Dimethyl-3-oxo-cyclohex-1-enyloxymethyl)-acrylic acid ethyl ester 
• 70092-96-5 2-Iodo-benzoic acid [3-hydroxy-5,5-dimethyl-cyclohex-2-en-(Z)-ylidene]-hydrazide 
• 70092-90-9 3-Methyl-benzoic acid [3-hydroxy-5,5-dimethyl-cyclohex-2-en-(Z)-ylidene]-hydrazide 
• 70092-84-1 5,5-Dimethyl-3-oxo-1-p-tolylhydrazino-1-cyclohexen 
• 70092-88-5 5,5-Dimethyl-3-hydroxy-1-oxo-2-cyclohexen-1-(N-benzyl-N-phenylhydrazon) 
• 70432-33-6 4-[(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-hydrazino]-5-oxo-2,5-dihydro-isoxazole-3-carboxylic acid ethyl ester 
• 17530-69-7 3-chloro-5,5-dimethylcyclohex-2-en-1-one 
• 13271-49-3 3-bromo-5,5-dimethlycyclohex-2-en-1-one 
• 40345-45-7 6,6-dimethyl-1-oxy-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-one 
• 70092-92-1 4-Methoxy-benzoic acid [3-hydroxy-5,5-dimethyl-cyclohex-2-en-(Z)-ylidene]-hydrazide 
• 70092-85-2 5,5-Dimethylcyclohexan-1,2,3-trion-2-p-nitrobenzoylhydrazon-1,3-bis(phenylhydrazon) 
• 70106-76-2 5,5-Dimethylcyclohexan-1,2,3-trion-2-p-nitrobenzoylhydrazon-1,3-bis-(p-tolylhydrazon) 

Relevant academic research and scientific papers

Kinetic Studies of Fast Equilibrium by Means of High-Performance Liquid Chromatography. XVII. Separation of Tautomers of 1,3-Cyclohexanediones

Tautomers of 1,3-cyclohexanediones have been separated by means of low-temperature high-performance liquid chromatography (HPLC).The ratios of keto- and enol-forms have been found to be highly solvent dependent, which is explained in terms of solute-solvent and solute-solute hydrogen bonding.

Alkylation of methylene-active compounds with halo acetals and hydrolysis of the alkylation products

A preparative procedure has been proposed for the alkylation of CH acids with halo acetals and hydrolysis of the alkylation products to furan derivatives and lactones.

Solvent Effects on Keto-Enol Equilibria: Tests of Quantitative Models

The effect of solvent on the equilibrium constants between selected keto-enol isomer pairs has been determined.The protomeric systems studied are 5,5-dimethyl-1,3-cyclohexanedione (1), 2-methyl-1,3-cyclohexanedione (3), 3-oxabicyclo-2,9-dioxononane (5), 2,4-pentanedione (7), ethyl 3-oxobutanoate (9), and 9-anthracenone (11).A wide variety of theoretical and empirical solvation parameters have been tested in a multiparameter linear free energy format to model the changes in equilibria.The most successful correlations are obtained with the Kamlet-Taft polarity-polarizability and hydrogen-bonding terms, although the Swain A and B factors have advantages in same cases.In general, for the isomer pairs in which the enol cannot form an internal hydrogen bond (1-2, 3-4, and 11-12), the equilibria appear to be controlled almost completely by the hydrogen-bonding basicity of the solvent.For the isomer pairs 5-6, 7-8, and 9-10, in which intramolecular hydrogen bonding is possible, the polarity-polarizability effect dominates, although differential stabilization of the isomers by hydrogen bonding remains significant.