34716-54-6

Upstream product

• 20425-27-8 (2S,5R,6R)-6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 
• 908093-98-1 diazodiphenylmethane 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 551-16-6 6-Aminopenicillanic Acid 

Downstream Products

• 72334-07-7 5-benzoyloxy-6β-phthalimido-penicillanic acid benzhydryl ester 
• 34706-14-4 C₂₉H₂₄Cl₂N₂O₅S 
• 34706-15-5 (2S,5S,6R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 303730-67-8 (2S,5R,6S)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 54212-99-6 1ξ-oxo-6β-phthalimido-1λ⁴-penicillanic acid benzhydryl ester 
• 303730-68-9 diphenylmethyl (2S)-2-[(3R,4S)-4-chloro-3-phthalimido-2-oxazetidin-1-yl]-2-(1-chlorothio-1-methylethyl)-acetate 

Relevant academic research and scientific papers

Syntheses of (6S)-cephalosporins from 6-aminopenicillanic acid

Two practical routes to (6S,7S)-cephalosporins from 6-aminopenicillanic acid (6-APA) are described. In the first, 6-APA was converted to (2S,4S,5S,6S)-penicillin sulfoxide 49, which underwent Morin ring expansion to a protected (6S,7S)-cephem 50. In the s

Novel stereochemical manipulations of the penicillin nucleus

The synthesis of a homochiral C2-epipenicillin tert-butyl amide 1 from 6- β-phthalimidopenicillanic acid is described.