34730-20-6

Basic information

• Product Name: 2-ACETYL-4-CHLOROTHIOPHENE
• Synonyms: 2-ACETYL-4-CHLOROTHIOPHENE;2-Acetyl-4-chlorothiophene, 98;1-(4-chlorothien-2-yl)ethanone;1-(4-Chlorothiophen-2-yl)ethanone;Ethanone, 1-(4-chloro-2-thienyl)-;2-acetyl-4-chlopothiophene
• CAS NO: 34730-20-6
• Molecular Formula: C₆H₅ClOS
• Molecular Weight: 160.62
• EINECS: 1592732-453-0
• Product Categories: Sulfur compounds
• Mol File: 34730-20-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 263°Cat760mmHg
• Flash Point: 112.9°C
• Appearance: /
• Density: 1.334
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-ACETYL-4-CHLOROTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYL-4-CHLOROTHIOPHENE(34730-20-6)
• EPA Substance Registry System: 2-ACETYL-4-CHLOROTHIOPHENE(34730-20-6)

Safety Data

• Statements: 36
• Safety Statements: 26
• RIDADR: UN2810
• HazardClass: 6.1
• Hazardous Substances Data: 34730-20-6(Hazardous Substances Data)

Usage

General Description

2-Acetyl-4-chlorothiophene is a chemical compound with the molecular formula C6H5ClOS. It is a pale yellow liquid with a strong, sweet odor and is insoluble in water. 2-Acetyl-4-chlorothiophene is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and fragrance compounds. It is also employed in the production of dyes and other organic compounds. The compound is considered to have potential occupational and environmental hazards due to its flammability and toxicity. Overall, 2-Acetyl-4-chlorothiophene is an important building block in the chemical industry, playing a crucial role in the development of various products and materials.

InChI:InChI=1/C6H5ClOS/c1-4(8)6-2-5(7)3-9-6/h2-3H,1H3

Upstream product

• 88-15-3 2-Acetylthiophene 
• 17249-80-8 3-chlorothiophene 
• 108-24-7 acetic anhydride 
• 123418-66-6 1-(5-bromo-4-chlorothiophen-2-yl)ethan-1-one 
• 57681-59-1 1-(4,5-Dichlor-2-thienyl)-ethanon 

Downstream Products

• 570407-10-2 4-(4-chlorothiophen-2-yl)-1,3-thiazol-2-amine 
• 1415915-79-5 C₁₇H₈Cl₂F₆O₂S₂ 
• 1446418-83-2 1-(3-chloro-5'-pyridin-2-yl-[2,2']bithiophenyl-5-yl)ethanone 
• 123418-66-6 1-(5-bromo-4-chlorothiophen-2-yl)ethan-1-one 
• 59614-95-8 4-Chloro-2-thiophenecarboxylic Acid 
• 80577-93-1 5-acetylthiophene-3-carbonitrile 
• 1449075-17-5 C₁₈H₈Cl₂F₈O₂S₂ 
• 1397709-68-0 ethyl 5-(5-acetyl-3-chlorothiophen-2-yl)-2-aminobenzoate 
• 1397709-48-6 1-[5-(4-aminophenyl)-4-chlorothiophen-2-yl]ethanone 
• 1397709-37-3 1-[5-(3-aminophenyl)-4-chlorothiophen-2-yl]ethanone 
• 1397709-51-1 1-[5-(2-aminophenyl)-4-chlorothiophen-2-yl]ethanone 
• 1393709-55-1 1-[4-chloro-5-(6-fluoropyridin-3-yl)-thiophen-2-yl]-ethanone 
• 1393709-42-6 5-(5-acetyl-3-chlorothiophen-2-yl)-nicotinonitrile 
• 1393709-32-4 1-[5-(5-acetylpyridin-3-yl)-4-chlorothiophen-2-yl]-ethanone 

Relevant articles and documents

Method for synthesizing 2-acetyl-4-chlorothiophene

The invention provides a method for synthesizing 2-acetyl-4-chlorothiophene, which comprises the following steps: dissolving 2-acetylthiophene in a solvent, adding a chlorinating agent and a Lewis acid, and reacting to obtain the 2-acetyl-4-chlorothiophene, wherein the chlorinating agent is N-chlorosuccinimide. The method is simple to operate, the synthesized 2-acetyl-4-chlorothiophene is high inyield and purity which can reach 99.66%, the raw material conversion rate is high, and few byproducts are produced. Meanwhile, the solid N-chlorosuccinimide is used as the chlorinating agent in the synthesis process of the method, and the chlorinating agent is low in cost, environmentally friendly, convenient to use and easy to control in dosage. Therefore, the method for synthesizing the 2-acetyl-4-chlorothiophene also has the advantages of low cost and environmental friendliness, is suitable for industrial large-scale production, and has a good market prospect.

Synthesis method of 4-chlorothiophene-2-carbonyl derivative

The invention discloses a synthesis method of a 4-chlorothiophene-2-carbonyl derivative. A thiophene-2-carbonyl derivative is used as a raw material and reacts with symclosene and aluminum trichloride, and liquid separation and concentration are performed to obtain the 4-chlorothiophene-2-carbonyl derivative. The synthesis method adopts one-step reaction, the yield is not lower than 80%, the production process is decreased while the yield is improved, and the cost is reduced; the used raw materials and reagents are easy to obtain, reaction conditions are mild, post-treatment and purification is easy to operate, and large-scale production can be achieved.

INHIBITORS OF Akt ACTIVITY

Invented are novel thiophene compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.