347361-14-2Relevant academic research and scientific papers
Synthesis of a phosphotyrosyl analogue having χ1, χ2 and φ angles constrained to values observed for an SH2 domain-bound phosphotyrosyl residue
Wang, Xiang-Zhu,Yao, Zhu-Jun,Liu, Hongpeng,Zhang, Manchao,Yang, Dajun,George, Clifford,Burke Jr., Terrence R.
, p. 6087 - 6093 (2003)
Src homology 2 (SH2) domains provide connectivity in protein-tyrosine kinase (PTK)-dependent signaling through their high affinity association with phosphotyrosyl (pTyr)-containing peptide sequences. Because recognition of pTyr residues is central to SH2
