347376-10-7Relevant articles and documents
Ring-expansion protocol: Preparation of synthetically versatile dihydrotropones
Do, Young-Sun,Sun, Ruiying,Kim, Hee Jin,Yeo, Jung Eun,Bae, Sung-Hee,Koo, Sangho
scheme or table, p. 917 - 920 (2009/06/20)
A ring-expansion protocol that consisted of the 1,2-addition of various enolate nucleophiles to 6-trimethylsiloxy-2- cyclohexene-1-one (1) and the NaIO4-promoted oxidative ring opening of the resulting diols 2, followed by an intramolecular Kno
Influence of Michael acceptor stereochemistry on intramolecular Morita-Baylis-Hillman reactions
Teng, Wen-Dong,Huang, Rui,Kwong, Cathy Kar-Wing,Shi, Min,Toy, Patrick H.
, p. 368 - 371 (2007/10/03)
A study of the effect of Michael acceptor stereochemistry on the efficiency of intramolecular Morita-Baylis-Hillman (MBH) reactions has been performed. The reactions were catalyzed by a phosphine, and the reaction substrates studied were enones containing
Assessing the scope of the tandem Michael/intramolecular aldol reaction mediated by secondary amines, thiols and phosphines
Richards, Elinor L,Murphy, Patrick J,Dinon, Francesca,Fratucello, Silvia,Brown, Paul M,Gelbrich, Thomas,Hursthouse, Michael B
, p. 7771 - 7784 (2007/10/03)
The outcome of a tandem Michael/intramolecular aldol reaction which is mediated by secondary amines, thiols and phosphines has been found to be highly substrate dependent, with the best results being obtained for the formation of 5 and 6-membered rings using thiol or thiolate nucleophiles. Amine and phosphine mediated cyclisations were found to be problematic in several cases but were still effective methods for the formation of 5-7 membered rings.
