347376-10-7Relevant academic research and scientific papers
Ring-expansion protocol: Preparation of synthetically versatile dihydrotropones
Do, Young-Sun,Sun, Ruiying,Kim, Hee Jin,Yeo, Jung Eun,Bae, Sung-Hee,Koo, Sangho
scheme or table, p. 917 - 920 (2009/06/20)
A ring-expansion protocol that consisted of the 1,2-addition of various enolate nucleophiles to 6-trimethylsiloxy-2- cyclohexene-1-one (1) and the NaIO4-promoted oxidative ring opening of the resulting diols 2, followed by an intramolecular Kno
Enantioselective catalysis of intramolecular Morita-Baylis-Hillman and related reactions by chiral rhenium-containing phosphines of the formula (η5-C5H5)Re(NO)(PPh3)(CH 2PAr2)
Seidel, Florian,Gladysz, John A.
, p. 986 - 988 (2008/02/03)
The racemic rhenium-containing phosphine (η5-C 5H5)Re(NO)(PPh3)(CH2PPh 2) catalyzes intramolecular Morita-Baylis-Hillman reactions of four R(CO)CH=CH(CH2)nCH2/su
Influence of Michael acceptor stereochemistry on intramolecular Morita-Baylis-Hillman reactions
Teng, Wen-Dong,Huang, Rui,Kwong, Cathy Kar-Wing,Shi, Min,Toy, Patrick H.
, p. 368 - 371 (2007/10/03)
A study of the effect of Michael acceptor stereochemistry on the efficiency of intramolecular Morita-Baylis-Hillman (MBH) reactions has been performed. The reactions were catalyzed by a phosphine, and the reaction substrates studied were enones containing
The intramolecular Baylis-Hillman reaction: Easy preparation of versatile substrates, facile reactions, and synthetic applications
Yeo, Jung Eun,Yang, Xiuling,Kim, Hee Jin,Koo, Sangho
, p. 236 - 237 (2007/10/03)
We have developed a general and highly efficient method for the preparation of diverse ω-formyl-aα,β-unsaturated carbonyl compounds and optimized the conditions for the intramolecular Baylis-Hillman reactions of these compounds to provide various biologic
Assessing the scope of the tandem Michael/intramolecular aldol reaction mediated by secondary amines, thiols and phosphines
Richards, Elinor L,Murphy, Patrick J,Dinon, Francesca,Fratucello, Silvia,Brown, Paul M,Gelbrich, Thomas,Hursthouse, Michael B
, p. 7771 - 7784 (2007/10/03)
The outcome of a tandem Michael/intramolecular aldol reaction which is mediated by secondary amines, thiols and phosphines has been found to be highly substrate dependent, with the best results being obtained for the formation of 5 and 6-membered rings using thiol or thiolate nucleophiles. Amine and phosphine mediated cyclisations were found to be problematic in several cases but were still effective methods for the formation of 5-7 membered rings.
An intramolecular Baylis-Hillman reaction catalysed by secondary amines
Black, Gregory P.,Dinon, Francesca,Fratucello, Silvia,Murphy, Patrick J.,Nielsen, Michael,Williams, Harri Lloyd,Walshe, Nigel D. A.
, p. 8561 - 8564 (2007/10/03)
Treatment of enonealdehydes 4 or 7 with a catalytic amount of a secondary amine lead to the formation of the cyclopentenol 5 or cyclohexenol 8 respectively. Piperidine proved to be the most effective catalyst for this process.
