3477-03-0

Basic information

• Product Name: 5-bomo-4-methyl-3-phenylisoxazole
• Synonyms: 5-bomo-4-methyl-3-phenylisoxazole
• CAS NO: 3477-03-0
• Molecular Weight: 238.084
• Mol File: 3477-03-0.mol

Chemical Properties

• CAS DataBase Reference: 5-bomo-4-methyl-3-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bomo-4-methyl-3-phenylisoxazole(3477-03-0)
• EPA Substance Registry System: 5-bomo-4-methyl-3-phenylisoxazole(3477-03-0)

Safety Data

• Hazardous Substances Data: 3477-03-0(Hazardous Substances Data)

Upstream product

• 23244-37-3 4-methyl-3-phenylisoxazole-5(4H)-one 
• 10488-87-6 ethyl 2-benzoylpropionate 

Downstream Products

• 10557-77-4 4-methyl-3,5-diphenylisoxazole 
• 24956-37-4 3-phenyl-4-methylisoxazole 
• 25388-17-4 toluene-4-sulfonic acid N'-(4-methyl-3-phenyl-isoxazol-5-yl)-hydrazide 
• 25388-14-1 5-(3,5-dimethyl-pyrazol-1-yl)-4-methyl-3-phenyl-isoxazole 
• 25388-11-8 benzaldehyde (4-methyl-3-phenyl-isoxazol-5-yl)-hydrazone 
• 25388-07-2 5-hydrazino-4-methyl-3-phenyl-isoxazole 

Relevant articles and documents

Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles

The Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles 1 at the C5 position has successfully proceeded in the presence of Pd2(dba)3 and P(t-Bu)3·HBF4 catalysts to give the corresponding trisubstituted isoxazoles 3 in good to high yields while suppressing the formation of ketone 4 as a byproduct. The use of bulky phosphine ligand P(t-Bu)3·HBF4 is essential for the current transformation, and the formation of ketone 4, which was a major product in the previous report, was able to be suppressed under the current conditions.