34790-85-7

Upstream product

• 926025-90-3 tert-butyl 3-(4-chlorobenzylamino)propylcarbamate 
• 1852-17-1 3,4,5,6-tetrahydropyrimidin-2(1H)-one 
• 622-95-7 4-chlorobenzyl bromide 

Downstream Products

• 1076243-04-3 1-(4-chlorobenzyl)-3-(oxiran-2-ylmethyl)tetrahydropyrimidin-2(1H)-one 
• 1076242-91-5 N-(2-{(2S)-3-[3-(4-chlorobenzyl)-2-oxotetrahydropyrimidin-1(2H)-yl]-2-hydroxypropyloxy}-4-methoxyphenyl)acetamide 
• 1216943-90-6 1-(4-chlorobenzyl)hexahydropyrimidine-2-thione 
• 1076242-89-1 N-(5-chloro-2-{3-[3-(4-chlorobenzyl)-2-oxotetrahydropyrimidin-1(2H)-yl]-2-hydroxypropoxy}-4-methoxyphenyl)acetamide 
• 1076242-92-6 N-(2-{(2S)-3-[3-(4-chlorobenzyl)-2-oxotetrahydropyrimidin-1(2H)-yl]-2-hydroxypropyloxy}-4-hydroxyphenyl)acetamide 
• 1076242-90-4 N-(2-{3-[3-(4-chlorobenzyl)-2-oxotetrahydropyrimidin-1(2H)-yl]-2-hydroxypropoxy}phenyl)acetamide 

Relevant academic research and scientific papers

Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis

The series of imidazoldine-2-thiones 2 and tetrahydropyrimidine-2-thiones 3 were discovered as inhibitor of α-MSH-induced melanin production in melanoma B16 cells. The primary bioassay showed that 1-(4-ethylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3e (>1

NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES

The present invention relates to new compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Q, X, Y, Z, A, R1, R2, R3, R4, R5 and m, q and p are defined as in claim 1, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions comprising said compounds and to the use of said compounds in therapy.

1-(Substituted benzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidones: A series with stimulant and depressant activities

A series of 1-(substituted benzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidones was synthesized primarily by catalytic hydrogenation of the corresponding 1-(substituted benzyl)-2(1H)-pyrimidone. The pharmacological evaluation of these compounds in mice revealed a