34793-65-2

Upstream product

• 51118-08-2 1,5-bis(4-chlorophenyl)penta-1,4-diyn-3-ol 
• 77295-59-1 1-chloro-4-(2,2-dibromovinyl)benzene 
• 873-73-4 4-n-chlorophenylacetylene 

Downstream Products

• 1469-91-6 2,6-bis(4-chlorophenyl)-4H-pyran-4-one 
• 51118-06-0 1,4-bis(4-chlorophenyl)buta-1,3-diyne 

Relevant academic research and scientific papers

Bronsted acid catalyzed and NIS-promoted cyclization of diynones: Selective synthesis of 4-pyrone, 4-pyridone, and 3-pyrrolone derivatives

Bronsted acid catalyzed tandem cyclization was found to be highly effective for the preparation of a series of polysubstituted 4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone derivatives were also selectively synthesized by employing NIS and/or Bronsted acid. NIS as an electrophilic reagent could promote these reactions efficiently and rapidly under very mild reaction conditions.

Rh(I)-catalyzed decarbonylation of diynones via C-C activation: Orthogonal synthesis of conjugated diynes

Utilization of C-C bond activation as a unique mode of reactivity for constructing C-C bonds provides new strategies for preparing important organic molecules. Development of a Rh(I)-catalyzed C-C activation of diynones to synthesize symmetrical and unsymmetrical conjugated diynes through decarbonylation is reported. This C-C cleavage strategy takes advantage of the innate reactivity of conjugated ynones without relying on any ring strain or auxiliary directing group. This alkynation method also has orthogonal properties compared to typical cross-coupling reactions.