34798-80-6

Usage

Uses

Used in Pharmaceutical Industry:
Methyl (4-phenyl-4-piperidyl) ketone is used as a precursor in the synthesis of pharmaceutical drugs for its ability to be converted into various active ingredients.
Used in Chemical Industry:
Methyl (4-phenyl-4-piperidyl) ketone is used as an intermediate in the production of organic compounds such as pesticides, dyes, and fragrances due to its versatile chemical properties.
Regulatory Note:
Due to its potential use in the illicit production of controlled substances, methyl (4-phenyl-4-piperidyl) ketone is considered a regulated chemical in many countries, highlighting the need for oversight in its production and distribution.

InChI:InChI=1S/C13H17NO/c1-11(15)13(7-9-14-10-8-13)12-5-3-2-4-6-12/h2-6,14H,7-10H2,1H3

Upstream product

• 10315-03-4 4-Acetyl-4-phenylpiperidine hydrochloride 

Downstream Products

• 26369-14-2 1-{1-[3-(2-chloro-phenothiazin-10-yl)-propyl]-4-phenyl-piperidin-4-yl}-ethanone 
• 686347-26-2 1-{1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}-ethanone, hydrochloride salt 

Relevant academic research and scientific papers

METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

4-phenyl-4-phenylpropyl(enyl)-piperidines as tachykinin antagonists

The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts and prodrugs thereof, wherein X represents a propylene or propenylene chain optionally substituted by one or more of R4, R5, R6 and R7 ; m is 2, 3 or 4; n is 0, 1 or 2 when m is 2 or 3, and n is 0 or 1 when m is 4; R1 represents optionally substituted phenyl; R2 represents optionally substituted phenyl, heteroaryl, benzhydryl or benzyl; R3 represents H, COR9, CO2 R10, COCONR10 R11, COCO2 R10, SO2 R15, CONR10 SO2 R15, C1-6 alkyl optionally substituted by a group selected from (CO2 R10, CONR10 R11, hydroxy, cyano, COR9, NR10 R11, C(NOH)NR10 R11, CONHphenyl(C1-4 alkyl), COCO2 R10, COCONR10 R11, SO2 R15, CONR10 SO2 R15 and optionally substituted phenyl), Y--R8 or CO--Z--(CH2)q --R12 ; R4 and R5 each independently represent H, C1-6 alkyl, C3-6 cycloalkyl, C3-5 cycloalkylmethyl, hydroxy or C1-6 alkoxy, or R4 and R5 together form a group =O; R6 and R7 each independent represents H, C1-6 alkyl, C3-6 cycloalkyl, C3-5 cycloalkylmethyl, hydroxy or C1-6 alkoxy or R6 and R7 together form a group =O; R8 represents an optionally substituted aromatic heterocycle; R9 represents H, C1-6 alkyl, C3-6 cycloalkyl, C3-5 cycloalkylmethyl, or phenyl; R10 and R11 each independently represent H, C1-6 alkyl, C3-6 cycloalkyl or C3-5 cycloalkylmethyl; R12 represents NR13 R14 or an optionally substituted aromatic or non-aromatic azacyclic or azabicyclic group; R13 and R14 each independently represent H, C1-6 alkyl, C3-6 cycloalkyl, C3-5 cycloalkylmethyl, optionally substituted phenyl or phenylC1-4 alkyl; R15 represents C1-6 alkyl, C3-6 cycloalkyl, C3-5 cycloalkylmethyl, trifluoromethyl or optionally substituted phenyl; Y represents a hydrocarbon chain of 1, 2, 3 or 4 carbon atoms which may optionally be substituted by oxo; Z represents CH2, O, S or NR10 ; and q represents 0, 1, 2, 3, 4, 5 or 6. The compounds are tachykinin antagonists useful for treating pain or inflammation, migraine or emesis.