348-25-4

Basic information

• Product Name: 6-FLUORO (1H)INDAZOLE
• Synonyms: 6-FLUORO (1H)INDAZOLE;1H-Indazole, 6-fluoro-;6-Fluoroindazole;6-Fluoro (1H)indazol;6-Fluoroindazol
• CAS NO: 348-25-4
• Molecular Formula: C₇H₅FN₂
• Molecular Weight: 136.13
• Mol File: 348-25-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 126 °C (decomp)
• Boiling Point: 274.892 °C at 760 mmHg
• Flash Point: 120.051 °C
• Appearance: /
• Density: 1.371 g/cm³
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.659
• Storage Temp.: 2-8°C
• PKA: 13.21±0.40(Predicted)
• CAS DataBase Reference: 6-FLUORO (1H)INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO (1H)INDAZOLE(348-25-4)
• EPA Substance Registry System: 6-FLUORO (1H)INDAZOLE(348-25-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 348-25-4(Hazardous Substances Data)

Usage

Uses

6-Fluoro-1H-indazole

InChI:InChI=1/C7H5FN2/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,(H,9,10)

Upstream product

• 59142-68-6 2-bromo-4-fluorobenzaldehyde 

Downstream Products

• 633327-51-2 5-nitro-6-fluoro-1H-indazole 
• 1178530-56-7 6-fluoro-3-{1-[(4-methylphenyl)sulfonyl]-3-phenylpropyl}-1H-indazole 

Relevant articles and documents

A novel copper-catalyzed, hydrazine-free synthesis of N-1 unsubstituted 1H-indazoles using stable guanylhydrazone salts as substrates

A CuI-catalyzed, hydrazine-free transformation of 2-(2-bromoarylidene)guanylhydrazone hydrochlorides using Cs2CO3 as a base and DMEDA as a ligand at 120 °C for 5 h delivers substituted 1H-indazoles with yields up to 75%. The C,N double bond configuration of the substrates was determined by NMR experiments and quantum chemical calculations. The reaction mechanism was studied using quantum chemical calculations.