348-35-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Fluorophenyl)-5-nitrobenzimidazole, 95% is used as a pharmaceutical intermediate for the production of various medications. Its unique chemical structure, which includes a nitro group and a fluorophenyl group, allows it to be incorporated into the synthesis of a wide range of pharmaceutical compounds. The high purity level of 95% ensures that the compound is suitable for use in research and manufacturing processes, where a high level of purity is required to achieve the desired therapeutic effects and minimize potential side effects.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 99-56-9 4-Nitrophenylene-1,2-diamine 

Downstream Products

• 1440142-05-1 C₂₀H₁₄FN₃O 
• 1372128-51-2 C₂₀H₁₃FN₄O₃ 
• 1440142-11-9 C₂₀H₁₃ClFN₃O 
• 1440142-14-2 C₂₁H₁₆FN₃O₂ 
• 863869-96-9 2-(4-fluorophenyl)-1H-benzo[d]imidazole-5-amine 
• 1223478-11-2 N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide 
• 1241617-48-0 N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)pyrazine-2-carboxamide 
• 1593834-60-6 N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine 

Relevant academic research and scientific papers

Highly chemoselective synthesis of benzimidazoles in Sc(OTf)3-catalyzed system

The present researches elicit a simple, green and efficient method for the synthesis of substituted benzimidazoles through the coupling of o-phenylenediames with aldehydes catalyzed by Sc(OTf)3 in ethanol, which obtains high chemoselectivity and excellent yield of many biologically active 1,2-disubstitued and 2-substituted benzimidazoles respectively and are also environment friendly.

Synthesis, p38 kinase inhibitory and anti-inflammatory activity of new substituted benzimidazole derivatives

P38 mitogen activated protein kinases have been found to involve in the production and release of unwarranted levels of pro-inflammatory cytokines including TNFα and IL-1β in numerous inflammatory diseases. A new series of molecules, 5-substituted benzoylamino-2-substituted phenylbezimidazoles has been synthesized from 4-nitro-1, 2-diaminobenzene. The synthesized compounds were characterized by FTIR, 1HNMR and Mass. The final compounds were screened for in vitro p38 kinase inhibitory and in vivo anti-inflammatory activity. Three compounds from the series demonstrated nearly 50percent inhibition of p38 kinase in the in vitro screening method at 10 μM concentration and two molecules exhibited greater than 75percent inhibition of paw oedema volume during the first hour. The docking study of synthesized molecule revealed a new binding pose in ATP binding pocket.

Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors

Multi-target EGFR, VEGFR-2 and PDGFR inhibitors are highly useful anticancer agents with improved therapeutic efficacies. In this work, we used two virtual screening methods, support vector machines (SVM) and molecular docking, to identify a novel series

Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity

Selective GABAA receptor ligands are widely used clinically to reduce the occurrence of convulsions. Hence there is an intense interest in developing new benzimidazole derivatives demonstrating high selectivity and high affinity for GABAA

H2O2/Fe(NO3)3-promoted synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles

A new, convenient synthesis of 2-substituted benzimidazoles and benzothiazoles is described. Short reaction time, easy and quick isolation of the products, environmentally friendly procedure, excellent chemoselectivity and excellent yields are main advantages of this procedure. Georg Thieme Verlag Stuttgart.

Mild and highly efficient method for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles

(Chemical Equation Presented) A new, convenient method for the syntheses of 2-substituted benzimidazole and benzothizole is described. Short reaction times, large-scale synthesis, easy and quick isolation of the products, excellent chemoselectivity, and excellent yields are the main advantages of this procedure.

Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production

Heterocyclic amidines with anti-inflammatory and analgesic activity that inhibit nitrogen oxide production, of formula (I): in which:G1 and G2 are hydrogen, halogen, hydroxyl, C1-C4 alkoxy, C1-C4 alkyl, and an amidino substituent of formula Q, provided that, for each compound of formula (I), only one of the two substituents G1 or G2 is an amidino substituent of formula Q: and in which the substituents W, Y and X are combined to form 9- or 10-membered bicyclic heteroaromatic derivatives containing up to 2 hetero atoms in the same ring; andZ is an aryl or heteroaryl group, a linear or branched C1-C6 alkyl or alkenyl chain, a C1-C4 alkyl-aryl group or a C1-C4 alkyl-heteroaryl group.

Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production

Heterocyclic amidines with anti-inflammatory and analgesic activity that inhibit nitrogen oxide production, of formula (I): in which: G1 and G2 are hydrogen, halogen, hydroxyl, C1-C4 alkoxy, C1-C4 alkyl, and an amidino substituent of formula Q, provided that, for each compound of formula (I), only one of the two substituents G1 or G2 is an amidino substituent of formula Q: and in which the substituents W, Y and X are combined to form 9- or 10-membered bicyclic heteroaromatic derivatives containing up to 2 hetero atoms in the same ring; and Z is an aryl or heteroaryl group, a linear or branched C1-C6 alkyl or alkenyl chain, a C1-C4 alkyl-aryl group or a C1-C4 alkyl-heteroaryl group.

Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species

New 2-substituted-phenyl-1H-benzimidazole-5-carboxylic acids (35, 38), ethyl-5-carboxylate (36), -5-carboxamides (37, 39),-5-carboxaldehyde (42), -5-chloro (40), -5-trifluoromethyl (41), and -5-carbonitriles (44-53, 55-67), -6-carbonitrile (54) were prepa