34804-85-8Relevant academic research and scientific papers
Selective Alkenylation and Hydroalkenylation of Enol Phosphates through Direct C-H Functionalization
Hu, Xu-Hong,Yang, Xiao-Fei,Loh, Teck-Peng
supporting information, p. 15535 - 15539 (2016/01/26)
An efficient and selective Rh-catalyzed direct C-H functionalization reaction of enol phosphates was developed. The method is applicable to a variety of coupling partners, including activated alkenes, alkynes, and allenes, and leads to the formation of various valuable alkenylated and hydroalkenylated enol phosphates through the action of the phosphate directing group. The versatility and utility of the coupling products were demonstrated through further transformations into synthetically useful building blocks. P points the way: A direct C-H functionalization of enol phosphates was developed. The method is applicable to a variety of coupling partners, including activated alkenes, alkynes, and allenes, and it leads to the formation of alkenylated and hydroalkenylated enol phosphates through the action of the phosphate directing group. The utility of the coupling products are demonstrated by further transformations into synthetically useful building blocks.
An efficient separation method for enol phosphate and corresponding β-ketophosphonate from their mixtures under aqueous conditions
Moorhoff, Cornelis M.
, p. 2069 - 2086 (2007/10/03)
Separation of a mixture β-ketophosphonate 3 and their corresponding enol phosphate 4 is efficiently carried out in aqueous alkaline solutions. Enol phosphate 4 is first extracted with hexanes:dichloromethane (19:1). Acidification of the aqueous layer followed by extraction of the β-ketophosphonate 3 with dichloromethane completes the separation. Thus, when 1-bromo-2,4-pentadione la reacted with triethyl phosphite to give diethyl (2,4-dioxopentyl)phosphonate 3a (Arbuzov-product) and the corresponding enol phosphate 4a (Perkow-product), separation of the two compounds was carried out using this method.
