348086-71-5 Usage
Uses
BAY 57-1293 is a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex.
Biological Activity
bay 57-1293 is a potent and safe inhibitor of hsv helicase-primase with ic50 value of 12nm [1].bay 57-1293 displays anti-herpes activity through inhibiting the helicase-primase and affecting the viral dna synthesis. in the in vitro viral replication assay, bay 57-1293 shows inhibition against hsv-1 f, hsv-2 g and acyclovir-resistant hsv-1 f mutant with ic50 value of 20nm. in the plaque reduction assay and the conventional cytopathogenicity assay, bay 57-1293 shows ic50 values of 0.01-0.02μm and 0.01-0.03μm, respectively. besides that, bay 57-1293 is active at an ic50 value of 10nm–30nm against all clinical isolates of hsv-1 and hsv-2. furthermore, bay 57-1293 is active in vivo. the oral administration of bay 57-1293 shows 10-fold more potent than valacyclovir in a murine model of disseminated herpes infection. in a rat lethal challenge model, bay 57-1293 exerts profound antiviral activity without toxic effects. [1, 2]
references
[1] kleymann g, fischer r, betz u a k, et al. new helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. nature medicine, 2002, 8(4): 392-398.[2] betz u a k, fischer r, kleymann g, et al. potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor bay 57-1293. antimicrobial agents and chemotherapy, 2002, 46(6): 1766-1772.
Check Digit Verification of cas no
The CAS Registry Mumber 348086-71-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,8,0,8 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 348086-71:
(8*3)+(7*4)+(6*8)+(5*0)+(4*8)+(3*6)+(2*7)+(1*1)=165
165 % 10 = 5
So 348086-71-5 is a valid CAS Registry Number.
