348135-65-9Relevant academic research and scientific papers
Investigation of the synthesis of angular tricyclic compounds by intramolecular Pauson-Khand reaction of exo- and endo-cyclic enynes
Ishizaki,Iwahara,Niimi,Satoh,Hoshino
, p. 2729 - 2738 (2007/10/03)
Intramolecular Pauson-Khand reaction of various alkynyl exo-alkylidene-cyclohexanes and -pentane gives angular type 6-5-5 and 5-5-5 tricyclic compounds in good to high yield. The present reaction also offers convenient construction of two contiguous quaternary centers, which could not be synthesized from alkynyl endo-cycloolefins. Scope and limitation of the present reaction of various exo- and endo-cyclic enynes are also described.
Titanocene catalysed 5-exo cyclisations of unsaturated epoxides- reagent control in radical chemistry
Gansaeuer,Pierobon,Bluhm
, p. 2500 - 2520 (2007/10/03)
A synthetic route to carbocyclic and heterocyclic [3.3.0], [4.3.0] and [5.3.0] systems containing pyrrolidine and tetrahydrofuran units and various other tetrahydrofuran derivatives is presented. The products are of relevance for natural product synthesis and for the synthesis of biologically active compounds. The titanocene catalysed reactions utilises readily available unsaturated epoxides as substrates. A model explaining the diastereoselectivity of cyclisation is presented that should allow for rational design of more selective catalysts.
