34815-70-8Relevant academic research and scientific papers
Titanocene(III)-Catalyzed Precision Deuteration of Epoxides
Gans?uer, Andreas,H?thker, Sebastian,Henriques, Dina Schwarz G.,Klare, Sven,Mika, Regine,Rojo-Wiechel, Elena,Schacht, Jonathan H.,Schmickler, Niklas
supporting information, (2021/12/24)
We describe a titanocene(III)-catalyzed deuterosilylation of epoxides that provides β-deuterated anti-Markovnikov alcohols with excellent D-incorporation, in high yield, and often excellent diastereoselectivity after desilylation. The key to the success of the reaction is a novel activation method of Cp2TiCl2 and (tBuC5H4)2TiCl2 with BnMgBr and PhSiD3 to provide [(RC5H4)2Ti(III)D] without isotope scrambling. It was developed after discovering an off-cycle scrambling with the previously described method. Our precision deuteration can be applied to the synthesis of drug precursors and highlights the power of combining radical chemistry with organometallic catalysis.
Cobalt-Catalyzed Migrational Isomerization of Styrenes
Zhao, Jiajin,Cheng, Biao,Chen, Chenhui,Lu, Zhan
supporting information, p. 837 - 841 (2020/01/31)
An efficient cobalt-catalyzed migrational isomerization of styrenes was developed using the thiazoline iminopyridine (TIP) ligand. This reaction is operationally simple and atom-economical using readily available starting materials to access trisubstituted alkenes. Even when using a 0.1 mol % catalyst loading, the reaction could be conducted in neat and completed in 1 h with excellent conversion and high E stereoselectivity.
