34827-33-3 Usage
General Description
Norsalsolinol is a chemical compound that has been identified as a naturally occurring product of dopamine metabolism in the brain. It is primarily formed through the oxidative breakdown of dopamine, and has been implicated in various neurological disorders, including Parkinson's disease and addiction. Norsalsolinol has been found to have neurotoxic and neuroinflammatory effects, leading to the degeneration of dopaminergic neurons in the brain. Additionally, it has been shown to have reinforcing effects on drug-seeking behavior, making it an important target for research in the fields of neuroscience and addiction. The significance of norsalsolinol in neurological disorders and addiction makes it an important chemical compound to study in the search for new treatments and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 34827-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,8,2 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 34827-33:
(7*3)+(6*4)+(5*8)+(4*2)+(3*7)+(2*3)+(1*3)=123
123 % 10 = 3
So 34827-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO2/c11-8-3-6-1-2-10-5-7(6)4-9(8)12/h3-4,10-12H,1-2,5H2
34827-33-3Relevant articles and documents
6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline formation by iron mediated dopamine oxidation: A novel route to endogenous neurotoxins under oxidative stress conditions
Napolitano, Alessandra,Pezzella, Alessandro,Prota, Giuseppe
, p. 2833 - 2836 (2007/10/03)
Aerobic oxidation of dopamine mediated by iron ions gives 6,7- dihydroxy-1,2,3,4-tetrahydroisoquinoline (2) and 3,4-dihydroxybenzaldehyde (4) in yields up to 10% and 15%, respectively. Based on 13C labelling experiments, a reaction mechanism is proposed involving oxidative fission of the dopamine side chain to give 4 and formaldehyde, the latter giving 2 by Pictet-Spengler condensation with dopamine. This provides a novel route to endogenous generation of neurotoxic isoquinoline alkaloids under oxidative stress conditions.
