3483-60-1

Basic information

• Product Name: N-antipyrine-2,2-dimethylglutarimide
• CAS NO: 3483-60-1
• Molecular Weight: 327.383
• Mol File: 3483-60-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-antipyrine-2,2-dimethylglutarimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-antipyrine-2,2-dimethylglutarimide(3483-60-1)
• EPA Substance Registry System: N-antipyrine-2,2-dimethylglutarimide(3483-60-1)

Safety Data

• Hazardous Substances Data: 3483-60-1(Hazardous Substances Data)

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 2938-48-9 3,3-dimethyl glutaric acid anhydride 

Relevant articles and documents

Studies on new cyclic imides obtained from aminophenazone with analgesic properties / Potent effects of a 3,4-dichloromaleimide derivative

This paper describes the synthesis of new cyclic imides obtained by reaction with aminophenazone (CAS 58-15-1, 4-aminoantipyrine) and different anhydrides with further cyclization with acetic acid under reflux. Their Structures were confirmed by spectral data (IR and NMR) and elemental analysis. The analgesic activity of the synthesized compounds was investigated initially with the writhing test in mice and the most promising compound, a 3,4-dichloromaleimide derivative (3), was analyzed using other models of nociception. The results indicated that compound 3 exerts potent analgesic activity in mice, being more active than some reference drugs. The analgesia caused by this compound was not reversed by naloxone in the writhing test. In the hotplate test, compound 3 did not increase the latency period of pain induced by thermal stimuli, confirming that it does not interact with opioid systems.