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3484-08-0

2-methyl-3-nitro-1H-indole is an organic compound with the molecular formula C9H8N2O2. It is a derivative of indole, a heterocyclic aromatic organic compound, characterized by the presence of a methyl group at the 2nd carbon and a nitro group at the 3rd carbon position. This yellow crystalline solid is soluble in organic solvents and has a melting point of approximately 180°C. 2-methyl-3-nitro-1H-indole is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other chemical compounds. Due to its reactivity and potential applications, it is an important compound in the field of organic chemistry and drug development.

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  • 3484-08-0 Structure

  • Basic information

    1. Product Name: 2-methyl-3-nitro-1H-indole
    2. Synonyms: 2-methyl-3-nitro-1H-indole
    3. CAS NO:3484-08-0
    4. Molecular Formula: C9H8N2O2
    5. Molecular Weight: 176.17202
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 3484-08-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-methyl-3-nitro-1H-indole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-methyl-3-nitro-1H-indole(3484-08-0)
    11. EPA Substance Registry System: 2-methyl-3-nitro-1H-indole(3484-08-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3484-08-0(Hazardous Substances Data)

3484-08-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3484-08-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,8 and 4 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3484-08:
(6*3)+(5*4)+(4*8)+(3*4)+(2*0)+(1*8)=90
90 % 10 = 0
So 3484-08-0 is a valid CAS Registry Number.

3484-08-0Relevant articles and documents

Nitromethane as a reagent for the synthesis of 3-nitroindoles from 2-haloarylamine derivatives

Chesnokov,Ageshina,Maryanova,Rzhevskiy,Gribanov,Topchiy,Nechaev,Asachenko

, p. 2370 - 2377 (2020/12/31)

A new approach to the synthesis of 3-nitroindoles using palladium-catalyzed arylation of nitromethane with N-(2-bromoaryl)imidates was developed. A convenient and rapid method for cyclization of ethyl N-(2-nitromethylaryl)acetimidates to 2-methyl-3-nitro-1H-indoles was proposed.

Method for preparing nitroindole derivatives

-

Paragraph 0012, (2016/10/31)

The invention discloses a method for preparing nitroindole derivatives. The method comprises the following steps: dissolving indole derivatives, sodium nitrate and potassium persulfate in a solvent, and reacting at 60-100 DEG C to obtain the nitroindole d

Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling

Nguyen, Huy H.,Kurth, Mark J.

, p. 362 - 365 (2013/03/13)

A variety of N-aryl β-nitroenamines were effectively transformed into 3-nitroindoles in good yields and with complete regioselectivity via a rapid microwave (μW) assisted intramolecular arene-alkene coupling reaction. This report further demonstrates the versatility of this method by constructing 3-carboalkoxy-and 3-cyanoindoles. Optimization data, substrate scope, and applications are discussed.

Aromatic nitration under neutral conditions using N-bromosuccinimide/ silver(I) nitrate

Nowrouzi, Najmeh,Mehranpour, Abdol Mohammad,Bashiri, Elham,Shayan, Zohre

experimental part, p. 4841 - 4842 (2012/09/22)

The use of N-bromosuccinimide and silver nitrate as a convenient reagent system for the nitration of aromatic compounds under neutral and environmentally safer reaction conditions is described.

Design, synthesis, and biological evaluation of substituted-N-(thieno[2,3-b]pyridin-3-yl)-guanidines, N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)-guanidines

Bahekar, Rajesh H.,Jain, Mukul R.,Goel, Ashish,Patel, Dipam N.,Prajapati, Vijay M.,Gupta, Arun A.,Jadav, Pradip A.,Patel, Pankaj R.

, p. 3248 - 3265 (2008/02/07)

Sulfonylureas stimulate insulin secretion independent of the blood glucose concentration and therefore cause hypoglycemia in type 2 diabetic patients. Over the last years, a number of aryl-imidazoline derivatives have been identified that stimulate insulin secretion in a glucose-dependent manner. In the present study, we have developed three series of substituted N-(thieno[2,3-b]pyridin-3-yl)-guanidine (2a-l), N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidine (3a-l), and N-(1H-indol-3-yl)-guanidine (4a-l) as new class of antidiabetic agents. In vitro glucose-dependent insulinotropic activity of test compounds 2a-l, 3a-l, and 4a-l was evaluated using RIN5F (Rat Insulinoma cell) based assay. All the test compounds showed concentration-dependent insulin secretion, only in presence of glucose load (16.7 mmol). Some of the test compounds (2c, 3c, and 4c) from each series were found to be equipotent to BL 11282 (standard aryl-imidazoline), which indicated that the guanidine group acts as a bioisostere of imidazoline ring system.

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