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Usage

Uses

Used in Chemical Industry:
12-Hydroxyabietic acid is used as a raw material for the production of adhesives, varnishes, and paints, due to its unique chemical structure and properties.
Used in Bioenergy Applications:
12-Hydroxyabietic acid is used as a potential source for bioenergy, given its renewable nature and excellent biological activity.
Used in Biomedicine Applications:
12-Hydroxyabietic acid is used as a component in biomedicine, leveraging its biological activity for various medical applications.
Used in Hydrogel Applications:
12-Hydroxyabietic acid is used in the development of hydrogels, taking advantage of its properties to create materials with specific characteristics for various uses.
Used in Environmental Management:
12-Hydroxyabietic acid is used as a reference compound in environmental studies, particularly in assessing the potential harmful effects on aquatic life, to better understand and manage its environmental impact.

Upstream product

• 514-10-3 abietic acid 
• 79-54-9 levopimaric acid 

Relevant academic research and scientific papers

Further acidic constituents and neutral components of pinus massoniana Resin

The resin of Pinus massoniana Lamb. contains, in addition to those isolated in an earlier study, two new diterpene acids, viz. 15-hydroxy-7,13-abietadien-12-on-18-oic acid and 8(14)-podocarpen-7,13-dion-18-oic acid, and three new plant products, viz. 2β-hydroxy-8,11,13-abietatrien-18-oic acid, 7,13,15-abietatrien-18-oic acid, and 13-hdyroxy-8,11,13-podocarpatrien-18-oic acid. The above acids and four others from the resin were isolated as the p-nitrophenyl esters, and the structures of these were established from spectroscopic evidence. Also isolated were three neutral di- and sesquiterpenes.

Investigation of the Allergenic Principles from Colophony: Autoxidation, Synthesis, and Sensitization

The autoxidation of abietic acid (1a), levopimaric acid (2a), and dehydroabietic acid (3a) was studied and the compounds 3a as well as (after esterification) 8b, 9b, 10b, 11b (from 1a); 6b (from 2a); and 4b, 5b (from 3a) were isolated for the first time.Some derivatives (6a, 6b, 13b/14b, and 7b) were semi-synthezised.The isolated autoxidation products, the synthetic compounds and some polar fractions of natural colophony were tested for their sensitizing capacity.Compounds 4a, 10b, 16, and 18 as well as the combined polar fraction A-D of colophony show enhanced sensitizing capacity.Methylation of the acids to the ester significantly reduces their activity.Key Words: Resin acids, autoxidation of / Colophony, allergy of / Sensitizing potency