34844-38-7Relevant academic research and scientific papers
The cross-aldol reaction of hexafluoroacetone (HFA) with ketones catalyzed by an acid
Komata, Takeo,Matsunaga, Kei,Hirotsu, Yoshiki,Akiba, Shinya,Ogura, Katsuyuki
, p. 902 - 909 (2008/03/14)
The cross-aldol reactions of hexafluoroacetone (HFA) and ketones using an acid catalyst are reported. When concentrated sulfuric acid was employed as the catalyst, HFA reacted regioselectively with various ketones at 50-100 °C to give the aldol adducts (6) in good yields. The reaction is initiated by an acid-catalyzed transformation of the ketone into the corresponding enol that reacts with HFA. The obtained adducts (6) can be reduced with hydrogen under a Ru/C catalyst to lead to the corresponding fluorine-containing diols (13).
Processes for producing fluorine-containing 2,4-diols and their derivatives
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Page/Page column 10, (2008/06/13)
A process for producing a fluorine-containing 2,4-diol represented by the formula [4], wherein R1 represents a hydrogen atom or an acyclic or cyclic alkyl group having a carbon atom number of 1 to 7; R2 represents an acyclic or cyclic alkyl group having a carbon atom number of 1 to 7, a phenyl group, or a substituted phenyl group; and R1 and R2 are optionally bonded to each other to form a ring, includes reducing a hydroxy ketone represented by the formula [3], wherein R1 and R2 are defined as above, by hydrogen in the presence of a ruthenium catalyst.
