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348575-88-2

Optovin (348575-88-2) is a reversible photoactive TRPA1 activator that plays a significant role in the study of sensory neurons and motor behaviors in various organisms, including zebrafish and mice. It is known for its ability to stimulate human TRPA1 channels and is involved in structure-dependent photochemical reactions with redox-sensitive cysteine residues.

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  • 348575-88-2 Structure

  • Basic information

    1. Product Name: Optovin
    2. Synonyms: Optovin;5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone;Oprovin
    3. CAS NO:348575-88-2
    4. Molecular Formula: C15H13N3OS2
    5. Molecular Weight: 315.41322
    6. EINECS: N/A
    7. Product Categories: Inhibitors
    8. Mol File: 348575-88-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.38±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: Soluble in DMSO (up to 30 mg/ml)
    9. PKA: 7.65±0.50(Predicted)
    10. Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    11. CAS DataBase Reference: Optovin(CAS DataBase Reference)
    12. NIST Chemistry Reference: Optovin(348575-88-2)
    13. EPA Substance Registry System: Optovin(348575-88-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 348575-88-2(Hazardous Substances Data)

348575-88-2 Usage

Uses

Used in Neuroscience Research:
Optovin is used as a research tool for studying the activation of TRPA1 channels in sensory neurons. Its application is crucial in understanding the role of these channels in photodetection and their involvement in motor behaviors.
Used in Pharmaceutical Development:
Optovin serves as a potential candidate for the development of new drugs targeting TRPA1 channels, which may have therapeutic applications in various conditions related to sensory neuron function and motor behavior regulation.
Used in Optogenetics:
In optogenetics, Optovin is used as a means to control and manipulate the activity of specific neurons in living organisms. By activating TRPA1 channels, researchers can study the effects of these channels on motor behaviors and other neuronal functions in a controlled manner.
Used in Drug Screening and Testing:
Optovin is utilized in drug screening and testing processes to identify potential modulators of TRPA1 channels. This helps in the development of new therapeutic agents that can target these channels for various medical applications.

References

1) Kokel?et al. (2013),?Photochemical activation of TRPA1 channels in neurons and animals; Nat. Chem. Biol.,?9?257

Check Digit Verification of cas no

The CAS Registry Mumber 348575-88-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,8,5,7 and 5 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 348575-88:
(8*3)+(7*4)+(6*8)+(5*5)+(4*7)+(3*5)+(2*8)+(1*8)=192
192 % 10 = 2
So 348575-88-2 is a valid CAS Registry Number.

348575-88-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-?Thiazolidinone, 5-?[[2,?5-?dimethyl-?1-?(3-?pyridinyl)?-?1H-?pyrrol-?3-?yl]?methylene]?-?2-?thioxo-

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:348575-88-2 SDS

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