348601-49-0

Basic information

• Product Name: 3,5-dimethyl-N-(4-bromobenzylidene)aniline
• Synonyms: 3,5-dimethyl-N-(4-bromobenzylidene)aniline
• CAS NO: 348601-49-0
• Molecular Weight: 288.187
• Mol File: 348601-49-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5-dimethyl-N-(4-bromobenzylidene)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dimethyl-N-(4-bromobenzylidene)aniline(348601-49-0)
• EPA Substance Registry System: 3,5-dimethyl-N-(4-bromobenzylidene)aniline(348601-49-0)

Safety Data

• Hazardous Substances Data: 348601-49-0(Hazardous Substances Data)

Upstream product

• 108-69-0 3,5-dimethylaminoaniline 
• 1122-91-4 4-bromo-benzaldehyde 

Relevant articles and documents

Diastereoselective, multicomponent access to trans-2-aryl-4-arylamino-1,2, 3,4-tetrahydroquinolines via an AA′BC sequential four-component reaction and their application to 2-arylquinoline synthesis

The CAN-catalyzed reaction between 3,5-disubstituted anilines, vinyl ethers and aromatic aldehydes leads to trans-2-aryl-4-arylaminotetrahydroquinolines, in an AA′BC sequential multicomponent transformation related to the Povarov reaction that was also extended to the use of a second aniline as the C-4 substituent. The unusual trans stereochemistry was explained by stabilization of the corresponding intermediate by intramolecular hydrogen bonding. The presence of the 4-anilino substituent allowed adapting the method to the synthesis of 4-unsubstituted 2-arylquinolines, by treatment of the crude product from the MCR with FeCl3 in methanol.