348640-02-8

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-;1-[(4-methylphenyl)sulphonyl]-1H-pyrrolo[2,3-b]pyridine;N-Tosyl-7-azaindole
• CAS NO: 348640-02-8
• Molecular Formula: C₁₄H₁₂N₂O₂S
• Molecular Weight: 272.33
• Mol File: 348640-02-8.mol
• Article Data: 17

Chemical Properties

• Melting Point: 132-133℃
• Boiling Point: 470.3°C at 760 mmHg
• Flash Point: 238.2°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 5.11E-09mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-(348640-02-8)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-(348640-02-8)

Safety Data

• Hazardous Substances Data: 348640-02-8(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- is a chemical compound with the molecular formula C16H13NO2S. It is also known by its chemical name, 1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine. 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- belongs to the class of organic compounds known as pyrrolopyridines, which are compounds containing a pyrrolopyridine ring, which is a six-membered aromatic ring with a pyrrole at the 1-position and a pyridine at the 2-position. This chemical also contains a sulfonyl group, which is a functional group that consists of a sulfur atom bonded to two oxygen atoms and connected to an organic group. The compound may have various applications in the field of pharmaceuticals, agrochemicals, and materials science, among others.

InChI:InChI=1/C14H12N2O2S/c1-11-4-6-13(7-5-11)19(17,18)16-10-8-12-3-2-9-15-14(12)16/h2-10H,1H3

Upstream product

• 271-63-6 7-Azaindole 
• 98-59-9 p-toluenesulfonyl chloride 
• 13578-51-3 1-(4-toluenesulfonyl)-1H-1,2,4-triazole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 

Downstream Products

• 882033-36-5 1-(toluene-4-sulfonyl)-2-tributylstannanyl-1H-pyrrolo[2,3-b]pyridine 
• 1019436-10-2 2-methyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 10586-52-4 2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 910896-40-1 2-phenyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 1052629-04-5 C₂₅H₂₁N₅O₂S 
• 1052631-05-6 C₂₅H₂₁N₅O₂S 
• 226085-18-3 3-bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 866545-93-9 3-(2-(methylsulfonyl)pyrimidin-4-yl)-1-(tolyl-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 866545-92-8 3-(2-(methylthio)pyrimidin-4-yl)-1-(tolyl-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 866545-91-7 1-(4-methylbenzenesulfonyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine 
• 944842-54-0 decernotinib 

Relevant articles and documents

Defluorinative functionalization of Pd(II) fluoroalkyl complexes

When subjected to arylboranes, anionic trifluoromethyl and difluorobenzyl palladium(II) complexes undergo fluoride abstraction followed by 1,1-migratory insertion. The resulting intermediate fluoroalkyl species can be induced to undergo a subsequent transmetalation and reductive elimination from either an in situ formed fluoroboronate (FB(Ar3)-) or an exogenous boronic acid/ ester (ArB(OR)2) and nucleophilic activator, representing a net defluorinative arylation reaction. The latter method enabled a structurally diverse substrate scope to be prepared from either an isolated palladium-CF3 complex, or from Pd(PPh3)4 and other commercially available reagents.

Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrrolo[2,3-b]pyridine derivatives as potential anti-tumor agents

A class of 3-substituted 1H-pyrrolo[2,3-b]pyridine derivatives were designed, synthesized and evaluated for their in vitro biological activities against maternal embryonic leucine zipper kinase (MELK). Among these derivatives, the optimized compound 16h e

Electron Transfer Photoredox Catalysis: Development of a Photoactivated Reductive Desulfonylation of an Aza-Heteroaromatic Ring

Herein, we report a protocol for desulfonylation of aza-heteroaromatic rings via photoinduced electron transfer and hydrogen atom transfer. This general protocol has a wide substrate range and moderate to good yields. The utility of the method was demonstrated by the chemoselective desulfonylation of a molecule containing both an aliphatic and an aromatic sulfonamide. (Figure presented.).