348642-86-4

Basic information

• Product Name: 4-Benzyloxy-1-bromo-2-(1,2-dimethyl-propenyl)-benzene
• Synonyms: 4-Benzyloxy-1-bromo-2-(1,2-dimethyl-propenyl)-benzene
• CAS NO: 348642-86-4
• Molecular Weight: 331.252
• Mol File: 348642-86-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Benzyloxy-1-bromo-2-(1,2-dimethyl-propenyl)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzyloxy-1-bromo-2-(1,2-dimethyl-propenyl)-benzene(348642-86-4)
• EPA Substance Registry System: 4-Benzyloxy-1-bromo-2-(1,2-dimethyl-propenyl)-benzene(348642-86-4)

Safety Data

• Hazardous Substances Data: 348642-86-4(Hazardous Substances Data)

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 348642-85-3 4-bromo-3-(1-hydroxy-2,2-dimethyl-propyl)-phenol 
• 2973-80-0 2-bromo-5-hydroxybenzaldehyde 

Downstream Products

• 348642-87-5 3-[4-benzyloxy-2-(1,2-dimethyl-propenyl)-phenyl]-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 348642-88-6 6-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-8-isopropyl-8-methyl-1-oxo-3,3a,8,8a-tetrahydro-1H-2-aza-cyclopenta[a]indene-2-carboxylic acid tert-butyl ester 
• 348642-89-7 6-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-8-isopropyl-8-methyl-1-oxo-3,3a,8,8a-tetrahydro-1H-2-aza-cyclopenta[a]indene-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth

In view of its role in tumor promotion and signal transduction, protein kinase C (PKC) has proven to be an exciting target for cancer therapy. With the aid of molecular modeling, we rationally designed and stereoselectively synthesized a new class of rigidified pyrrolidone-based PKC activators. Pyrrolidone 15 was found to exhibit reasonable affinity for PKCδ, with lower affinity for the other isozymes tested. Pyrrolidone 2 causes the dose-dependent induction of apoptosis in LNCaP prostate cancer cells. This apoptotic effect could be markedly potentiated by the use of LNCaP cells overexpressing the PKCα or δ isozymes.